Evidence map›Paper›PMID 30409904›Full record

ArticleThe Journal of biological chemistry2019

Reciprocal negative regulation between the tumor suppressor protein p53 and B cell CLL/lymphoma 6 (BCL6) via control of caspase-1 expression.

Min-Kyeong Kim, Ji-Yang Song, Dong-In Koh, Jin Young Kim, Masahiko Hatano, Bu-Nam Jeon, Min-Young Kim, Su-Yeon Cho, Kyung-Sup Kim, Man-Wook Hur

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. The role of acetylation and deacetylation in cancer metabolism.Clinical and translational medicine · 2025
    Review
  2. Article
  3. Effect of caspase-1 (Translational cancer research · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Min-Kyeong KimBrain Korea 21 Plus Project for Medical Sciences, Severance Biomedical Research Institute, Department of Biochemistry and Molecular Biology, Yonsei University School of Medicine, 50 Yonsei-ro, SeoDaeMoon-gu, Seoul 03722, Korea.
Ji-Yang SongBrain Korea 21 Plus Project for Medical Sciences, Severance Biomedical Research Institute, Department of Biochemistry and Molecular Biology, Yonsei University School of Medicine, 50 Yonsei-ro, SeoDaeMoon-gu, Seoul 03722, Korea.
Dong-In KohBrain Korea 21 Plus Project for Medical Sciences, Severance Biomedical Research Institute, Department of Biochemistry and Molecular Biology, Yonsei University School of Medicine, 50 Yonsei-ro, SeoDaeMoon-gu, Seoul 03722, Korea.
Jin Young KimBiomedical Omics Group, Korea Basic Science Institute, 162 Yoengudanji-ro, Ochang, Chungbuk 28119, Korea.
Masahiko HatanoDepartment of Biomedical Science, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba City, Chiba 260-0856, Japan.
Bu-Nam JeonBrain Korea 21 Plus Project for Medical Sciences, Severance Biomedical Research Institute, Department of Biochemistry and Molecular Biology, Yonsei University School of Medicine, 50 Yonsei-ro, SeoDaeMoon-gu, Seoul 03722, Korea.
Min-Young KimBrain Korea 21 Plus Project for Medical Sciences, Severance Biomedical Research Institute, Department of Biochemistry and Molecular Biology, Yonsei University School of Medicine, 50 Yonsei-ro, SeoDaeMoon-gu, Seoul 03722, Korea.
Su-Yeon ChoBrain Korea 21 Plus Project for Medical Sciences, Severance Biomedical Research Institute, Department of Biochemistry and Molecular Biology, Yonsei University School of Medicine, 50 Yonsei-ro, SeoDaeMoon-gu, Seoul 03722, Korea.
Kyung-Sup KimBrain Korea 21 Plus Project for Medical Sciences, Severance Biomedical Research Institute, Department of Biochemistry and Molecular Biology, Yonsei University School of Medicine, 50 Yonsei-ro, SeoDaeMoon-gu, Seoul 03722, Korea.
Man-Wook HurBrain Korea 21 Plus Project for Medical Sciences, Severance Biomedical Research Institute, Department of Biochemistry and Molecular Biology, Yonsei University School of Medicine, 50 Yonsei-ro, SeoDaeMoon-gu, Seoul 03722, Korea. Electronic address: mwhur2@yuhs.ac.
Yonsei University · KRChiba University · JPKorea Basic Science Institute · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Even in the face of physiological DNA damage or expression of the tumor suppressor protein p53, B cell CLL/lymphoma 6 (BCL6) increases proliferation and antagonizes apoptotic responses in B cells. BCL6 represses

Indexed as

Gene Expression Regulation, EnzymologicAnimalsB-LymphocytesCaspase 1Cell Transformation, NeoplasticHCT116 CellsHEK293 CellsHumansMiceMice, KnockoutProto-Oncogene Proteins c-bcl-6Tumor Suppressor Protein p53Bcl6 protein, mouseCasp1 protein, mouseCaspase 1Proto-Oncogene Proteins c-bcl-6Trp53 protein, mouseTumor Suppressor Protein p53acetylationBCL6cancer developmentcaspase-1caspase 1 (CASP1)E1A binding protein p300 (P300)lymphocytelymphomamemory B cellp300p53post-translational modification (PTM)proteolysis

Identifiers

PMID30409904
PMCPMC6322868
OpenAlexW2900272452

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.