Evidence map›Paper›PMID 30409902›Full record

ArticleThe Journal of biological chemistry2019

Prostaglandin E

Kotha Subbaramaiah, Neil M Iyengar, Monica Morrow, Olivier Elemento, Xi Kathy Zhou, Andrew J Dannenberg

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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  8. Regulation of aromatase in cancer.Molecular and cellular biochemistry · 2021
    Review
  9. Observational
  10. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Kotha SubbaramaiahDepartment of Medicine, Weill Cornell Medical College, New York, New York 10065. Electronic address: ajdannen@med.cornell.edu.
Neil M IyengarDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065.
Monica MorrowDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065.
Olivier ElementoDepartments of Physiology and Biophysics, Weill Cornell Medical College, New York, New York 10065; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, New York 10065.
Xi Kathy ZhouHealthcare Policy and Research, Weill Cornell Medical College, New York, New York 10065.
Andrew J DannenbergDepartment of Medicine, Weill Cornell Medical College, New York, New York 10065. Electronic address: ksubba@med.cornell.edu.
Cornell University · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Project 3: Physical and Metabolic Constraints of Cancer Cell InvasionU54CA210184 · NCI · CORNELL UNIVERSITY · PI CANTLEY, LEWIS C., FISCHBACH, CLAUDIA · 2016 to 2020
$10.2M
Obesity Increases Breast Cancer Penetrance in BRCA Mutation Carriers: A Role for Local and Systemic FactorsR01CA215797 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BROWN, KRISTY A. · 2017 to 2021
$2.6M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA215797NCI NIH HHS U54 CA210184
6 · The paper itself

Abstract

Obesity increases the risk of hormone receptor-positive breast cancer in postmenopausal women. Levels of aromatase, the rate-limiting enzyme in estrogen biosynthesis, are increased in the breast tissue of obese women. Both prostaglandin E

Indexed as

AromataseBreast NeoplasmsCell Line, TransformedDinoprostoneFemaleHumansHypoxia-Inducible Factor 1, alpha SubunitNeoplasm ProteinsObesityp300-CBP-Associated Factorp300-CBP Transcription FactorsResponse ElementsResveratrolSirtuin 1AromataseCYP19A1 protein, humanDinoprostoneHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitNeoplasm Proteinsp300-CBP-Associated Factorp300-CBP Transcription FactorsResveratrolSIRT1 protein, humanSirtuin 1adipose tissuearomataseestrogenhypoxia-inducible factor (HIF)obesityprostaglandinsirtuin

Identifiers

PMID30409902
PMCPMC6322870
OpenAlexW2899696857

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.