Evidence map›Paper›PMID 30409834›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2019

Influence of Stereochemistry on the Bioactivation and Glucuronidation of 4-Ipomeanol.

Aaron M Teitelbaum, Matthew G McDonald, John P Kowalski, Oliver T Parkinson, Michele Scian, Dale Whittington, Katharina Roellecke, Helmut Hanenberg, Constanze Wiek, Allan E Rettie

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Aaron M TeitelbaumDepartment of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (A.M.T., M.G.M., J.P.K., O.T.P., M.S., D.W., A.E.R.); Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (K.R., H.H., C.W.); and Department of Pediatrics III, University, Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.) aaron.teitelbaum@boehringer-ingelheim.com.ORCID 0000-0001-6737-0928
Matthew G McDonaldDepartment of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (A.M.T., M.G.M., J.P.K., O.T.P., M.S., D.W., A.E.R.); Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (K.R., H.H., C.W.); and Department of Pediatrics III, University, Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
John P KowalskiDepartment of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (A.M.T., M.G.M., J.P.K., O.T.P., M.S., D.W., A.E.R.); Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (K.R., H.H., C.W.); and Department of Pediatrics III, University, Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
Oliver T ParkinsonDepartment of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (A.M.T., M.G.M., J.P.K., O.T.P., M.S., D.W., A.E.R.); Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (K.R., H.H., C.W.); and Department of Pediatrics III, University, Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
Michele ScianDepartment of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (A.M.T., M.G.M., J.P.K., O.T.P., M.S., D.W., A.E.R.); Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (K.R., H.H., C.W.); and Department of Pediatrics III, University, Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
Dale WhittingtonDepartment of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (A.M.T., M.G.M., J.P.K., O.T.P., M.S., D.W., A.E.R.); Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (K.R., H.H., C.W.); and Department of Pediatrics III, University, Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
Katharina RoelleckeDepartment of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (A.M.T., M.G.M., J.P.K., O.T.P., M.S., D.W., A.E.R.); Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (K.R., H.H., C.W.); and Department of Pediatrics III, University, Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
Helmut HanenbergDepartment of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (A.M.T., M.G.M., J.P.K., O.T.P., M.S., D.W., A.E.R.); Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (K.R., H.H., C.W.); and Department of Pediatrics III, University, Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
Constanze WiekDepartment of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (A.M.T., M.G.M., J.P.K., O.T.P., M.S., D.W., A.E.R.); Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (K.R., H.H., C.W.); and Department of Pediatrics III, University, Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
Allan E RettieDepartment of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (A.M.T., M.G.M., J.P.K., O.T.P., M.S., D.W., A.E.R.); Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (K.R., H.H., C.W.); and Department of Pediatrics III, University, Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
University of Washington · US

Funding

Pharmacological Sciences SupplementT32GM007750 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 1985 to 2023
$12.6M
MECHANISMS OF P450 DEPENDENT DESATURATIONR01GM049054 · NIGMS · UNIVERSITY OF WASHINGTON · PI RETTIE, ALLAN EDWARD · 1994 to 2010
$2.9M
NIGMS NIH HHS R01 GM049054NIGMS NIH HHS T32 GM007750
6 · The paper itself

Abstract

A potential CYP4B1 suicide gene application in engineered T-cell treatment of blood cancers has revived interest in the use of 4-ipomeanol (IPO) in gene-directed enzyme prodrug therapy, in which disposition of the administered compound may be critical. IPO contains one chiral center at the carbon bearing a secondary alcohol group; it was of interest to determine the effect of stereochemistry on 1) CYP4B1-mediated bioactivation and 2) (UGT)-mediated glucuronidation. First, (

Indexed as

Dose-Response Relationship, DrugGlucuronidesHep G2 CellsHumansMicrosomesStereoisomerismTerpenesToxins, Biological4-ipomeanolGlucuronidesTerpenesToxins, Biological

Identifiers

PMID30409834
PMCPMC6346377
OpenAlexW2900105538

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.