Evidence map›Paper›PMID 30409789›Full record

ArticleGenetics2019

Epithelial Shaping by Diverse Apical Extracellular Matrices Requires the Nidogen Domain Protein DEX-1 in

Jennifer D Cohen, Kristen M Flatt, Nathan E Schroeder, Meera V Sundaram

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. MLT-11 is necessary forbioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Pathways that affect anterior morphogenesis inbioRxiv : the preprint server for biology · 2023
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Epithelial morphogenesis, tubulogenesis and forces in organogenesis.Current topics in developmental biology · 2021
    Review
  18. Article
  19. Journal of developmental biology · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jennifer D CohenDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104.
Kristen M FlattProgram in Neuroscience, University of Illinois at Urbana-Champaign, Illinois 61801-4730.
Nathan E SchroederProgram in Neuroscience, University of Illinois at Urbana-Champaign, Illinois 61801-4730.ORCID 0000-0003-3327-2136
Meera V SundaramDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104 sundaram@pennmedicine.upenn.edu.ORCID 0000-0002-2940-8750
University of Illinois Urbana-Champaign · USUniversity of Pennsylvania · US

Funding

Penn Dermatology Research Training ProgramT32AR007465 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice, David Joel Margolis · 1986 to 2026
$9.0M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008216 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, DOUGLAS J · 1987 to 2023
$8.3M
VANADIUM INTERACTION STUDIES IN RELATION TO THE INHIBITION OF NA+-K+-ATPASES06GM008216 · NIGMS · UNIVERSITY OF PUERTO RICO AT HUMACAO · PI ALEGRIA, ANTONIO E · 1989 to 2010
$8.0M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Ras Signaling and Tubulogenesis in the C. elegans Excretory (renal) SystemR01GM058540 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SUNDARAM, MEERA · 2000 to 2019
$5.3M
Stress-induced phenotypic plasticity in C. elegansR01GM111566 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SCHROEDER, NATHAN · 2014 to 2018
$1.4M
NIAMS NIH HHS T32 AR007465NIGMS NIH HHS R01 GM058540NIGMS NIH HHS R01 GM111566NIGMS NIH HHS S06 GM008216NIGMS NIH HHS T32 GM008216NIH HHS P40 OD010440
6 · The paper itself

Abstract

The body's external surfaces and the insides of biological tubes, like the vascular system, are lined by a lipid-, glycoprotein-, and glycosaminoglycan-rich apical extracellular matrix (aECM). aECMs are the body's first line of defense against infectious agents and promote tissue integrity and morphogenesis, but are poorly described relative to basement membranes and stromal ECMs. While some aECM components, such as zona pellucida (ZP) domain proteins, have been identified, little is known regarding the overall composition of the aECM or the mechanisms by which different aECM components work together to shape epithelial tissues. In

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell DifferentiationEpithelial CellsExtracellular MatrixLoss of Function MutationMorphogenesisCaenorhabditis elegans ProteinsC. eleganscuticleexcretory systemextracellular matrixzona pellucida

Identifiers

PMID30409789
PMCPMC6325709
OpenAlexW2899623746

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.