ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2018
Relationship of Hippocampal Volumes and Posttraumatic Stress Disorder Symptoms Over Early Posttrauma Periods.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Moving beyond gender: a systematic review of diversity data gaps in prospective trauma research.European journal of psychotraumatology · 2025Pooled it
- The interactions between host genome and gut microbiome increase the risk of psychiatric disorders: Mendelian randomization and biological annotation.Brain, behavior, and immunity · 2023Pooled it
- Prefrontal cortical deficits are a putative susceptibility factor for PTSD.Frontiers in behavioral neuroscience · 2026Article
- Predicting PTSD development with early post-trauma assessments: a proof-of-concept for a concise tree-based classification method.European journal of psychotraumatology · 2025Article
- Weaving Invisible Threads: The Impact of Caregiver Trauma on Parenting and Child Brain Development.Brain sciences · 2025Review
- Article
- Impaired mnemonic pattern separation associated with PTSD symptoms paradoxically improves with regular cannabis use.Npj mental health research · 2025Article
- Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field.Molecular psychiatry · 2024Review
- Smaller Hippocampal Volume Is Associated With Reduced Posttraumatic Stress Symptoms in Children With Cancer and Survivors Following a Brief Novel Martial Arts-Based Intervention.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Trauma-related intrusive memories and anterior hippocampus structural covariance: an ecological momentary assessment study in posttraumatic stress disorder.Translational psychiatry · 2024Article
- Trauma and the default mode network: review and exploratory study.Frontiers in behavioral neuroscience · 2024Article
- Cortical volume alteration in the superior parietal region mediates the relationship between childhood abuse and PTSD avoidance symptoms: A complementary multimodal neuroimaging study.Neurobiology of stress · 2024Article
- Sex-Based Contributors to and Consequences of Post-traumatic Stress Disorder.Current psychiatry reports · 2023Review
- Longitudinal volumetric evaluation of hippocampus and amygdala subregions in recent trauma survivors.Molecular psychiatry · 2023Article
- Maternal separation in mice leads to anxiety-like/aggressive behavior and increases immunoreactivity for glutamic acid decarboxylase and parvalbumin in the adolescence ventral hippocampus.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023Article
- Association of age of adverse childhood experiences with thalamic volumes and post-traumatic stress disorder in adulthood.Frontiers in behavioral neuroscience · 2023Article
- Sex-dependent risk factors for PTSD: a prospective structural MRI study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications.Molecular psychiatry · 2022Review
- Amygdala and hippocampal subregions mediate outcomes following trauma during typical development: Evidence from high-resolution structural MRI.Neurobiology of stress · 2022Article
- Adverse childhood experiences associate with early post-trauma thalamus and thalamic nuclei volumes and PTSD development in adulthood.Psychiatry research. Neuroimaging · 2022Article
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Authors and funding
10 authors.
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Abstract
backgroundSmaller hippocampal volume is associated with more severe posttraumatic stress disorder (PTSD) symptoms years after traumatic experiences. Posttraumatic stress symptoms appear early following trauma, but the relationship between hippocampal volume and PTSD symptom severity during early posttrauma periods is not well understood. It is possible that the inverse relationship between hippocampal volume and PTSD symptom severity is already present soon after trauma. To test this possibility, we prospectively examined the association between hippocampal volumes and severity of PTSD symptoms within weeks to months after trauma due to a motor vehicle collision.
methodsStructural magnetic resonance imaging scans of 44 survivors were collected about 2 weeks and again at 3 months after a motor vehicle collision to measure hippocampal volumes. The PTSD Checklist was used to evaluate PTSD symptoms at each scan time. Full (n = 5) or partial (n = 6) PTSD was evaluated using the Clinician-Administered PTSD Scale at 3 months.
resultsLeft hippocampal volumes at both time points negatively correlated with PTSD Checklist scores, and with subscores for re-experiencing symptoms at 3 months. Left hippocampal volumes at 3 months also negatively correlated with hyperarousal symptoms at 3 months. Finally, neither left nor right hippocampal volumes significantly changed between 2 weeks and 3 months posttrauma.
conclusionsThe results suggest that small hippocampal volume at early posttrauma weeks is associated with increased risk for PTSD development. Furthermore, the inverse relationship between hippocampal volume and PTSD symptoms at 3 months did not arise from posttrauma shifts in hippocampal volume between 2 weeks and 3 months after trauma.
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