Evidence map›Paper›PMID 30409312›Full record

ArticleOral oncology2018

Routine surveillance scanning in HNSCC: Lung screening CT scans have value but head and neck scans do not.

Austin J Iovoli, Alexis J Platek, Luke Degraaff, Chong Wang, William D Duncan, Kimberly E Wooten, Hassan Arshad, Vishal Gupta, Moni A Kuriakose, Wesley L Hicks and 2 more

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Oral oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. NI-RADS in posttreatment head and neck cancer surveillance: a framework for standardized imaging with clinical impact.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026
    Review
  2. European Laryngological Society consensus statement on optimal monitoring schedules after treatment for early glottic cancer: a risk-stratification.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Austin J IovoliJacobs School of Medicine, 955 Main St, Buffalo, NY 14203, United States.
Alexis J PlatekJacobs School of Medicine, 955 Main St, Buffalo, NY 14203, United States.
Luke DegraaffJacobs School of Medicine, 955 Main St, Buffalo, NY 14203, United States.
Chong WangDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, 665 Elm St, Buffalo, NY 14203, United States.
William D DuncanDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, 665 Elm St, Buffalo, NY 14203, United States.
Kimberly E WootenDepartment of Head and Neck/Plastic and Reconstructive Surgery, Roswell Park Comprehensive Cancer Center, 665 Elm St, Buffalo, NY 14203, United States.
Hassan ArshadDepartment of Head and Neck/Plastic and Reconstructive Surgery, Roswell Park Comprehensive Cancer Center, 665 Elm St, Buffalo, NY 14203, United States.
Vishal GuptaDepartment of Head and Neck/Plastic and Reconstructive Surgery, Roswell Park Comprehensive Cancer Center, 665 Elm St, Buffalo, NY 14203, United States.
Moni A KuriakoseDepartment of Head and Neck/Plastic and Reconstructive Surgery, Roswell Park Comprehensive Cancer Center, 665 Elm St, Buffalo, NY 14203, United States.
Wesley L HicksDepartment of Head and Neck/Plastic and Reconstructive Surgery, Roswell Park Comprehensive Cancer Center, 665 Elm St, Buffalo, NY 14203, United States.
Mary E PlatekDepartment of Health, Nutrition & Dietetics, Buffalo State College, 1300 Elmwood Ave, Buffalo, NY 14222, United States; Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, 665 Elm St, Buffalo, NY 14203, United States.
Anurag K SinghDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, 665 Elm St, Buffalo, NY 14203, United States. Electronic address: Anurag.Singh@Roswellpark.org.
Roswell Park Comprehensive Cancer Center · USJacobs Institute · USBuffalo State University · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
NCI NIH HHS P30 CA016056
6 · The paper itself

Abstract

objectivesTo examine the utility of computed tomography (CT) imaging during routine surveillance for the detection of recurrent head and neck squamous cell carcinoma (HNSCC). MATERIALS/

methodsClinical characteristics of HNSCC patients treated between 2008 and 2017 with radiation therapy or concurrent chemoradiation were abstracted from medical records. In patients who achieved a complete response to treatment by positron emission tomography scan, surveillance CT scans were conducted to the maxillofacial area, neck, and chest every 3 months in year 1, every 6 months in year 2, and every 12 months in years 3 and beyond.

resultsWithin the entire cohort (n = 534), complete response was achieved in 446 patients (83.5%); of these, 84 (15.7%) patients had a recurrence. Among the 84 patients with disease recurrence, 25 (30%) patients remained alive, of which 15 (18%) underwent successful salvage treatment and became free of disease. Lung screening CT scans detected failure in 8 of these successfully salvaged patients. Among the 8 patients successfully salvaged for locoregional recurrence, 3 failures were asymptomatic at onset and detected by laryngoscope or dental exam. The remaining 5 failures were symptomatic and detected upon work up prompted by symptoms. Maxillofacial and neck surveillance CT imaging failed to detect any successfully salvaged patients.

conclusionsRoutine surveillance for HNSCC patients with lung CT imaging had value but routine head and neck CT scans failed to identify any successfully salvaged patients. Given this finding, routine CT imaging surveillance in HNSCC patients should be restricted to annual lung screening with low-dose chest CT.

Indexed as

AgedChemoradiotherapyFemaleFollow-Up StudiesHeadHead and Neck NeoplasmsHumansLung NeoplasmsMaleMass ScreeningMiddle AgedNeckNeoplasm Recurrence, LocalRetrospective StudiesSalvage TherapySquamous Cell Carcinoma of Head and NeckCarcinomaHead and neck neoplasmsNeoplasm recurrenceSalvage therapySquamous cellTomographyX-ray computed

Identifiers

PMID30409312
PMCPMC6961953
OpenAlexW2897549019

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.