ArticleBMC psychiatry2018
Impact of seasons on stroke-related depression, mediated by vitamin D status.
Article in BMC psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- The Role of Water-Soluble Vitamins and Vitamin D in Prevention and Treatment of Depression and Seasonal Affective Disorder in Adults.Nutrients · 2024Review
- Incidence of post-stroke depression symptoms and potential risk factors in adults with aphasia in a comprehensive stroke center.Topics in stroke rehabilitation · 2023Article
- Prevalence of vitamin D deficiency in patients with spinal cord injury at admission: a single-centred study in the UK.Journal of nutritional science · 2023Article
- Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke population.Frontiers in psychiatry · 2023Article
- Experiences of stroke survivors and measurement of post stroke participation and activity across seasons-A mixed methods approach.PloS one · 2021Article
- Status and influential factors of vitamin D among children aged 0 to 6 years in a Chinese population.BMC public health · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to describe the seasonal variation of depression prevalence among stroke patients at 1 month and to explore whether vitamin D plays a role in the association between seasons and post-stroke depression (PSD).
methodsData were collected from 402 acute stroke patients. Seasons were stratified by summertime (June to November) and wintertime (December to May) based on vitamin D status. The impact of seasons on PSD was assessed via binary logistic regression, with summertime considered the referent category. The mediating effect was used to evaluate whether vitamin D plays a role in the association between seasons and PSD.
resultsThe prevalence of PSD was significantly higher in the wintertime group than in the summertime group (P = 0.003). The serum vitamin D level was lower in wintertime than in summertime (P < 0.001). Lower vitamin D levels were associated with higher HAMD scores (P < 0.001). In the multivariate analysis, patients in the wintertime group had a higher prevalence of PSD compared with those in the summertime group across all binary logistic regression models after adjusting for potential confounders. When serum vitamin D was added to the above model, there was no association between seasons and PSD (P = 0.056). Vitamin D was independently associated with PSD (OR 0.95, 95% CI 0.935-0.966, P < 0.001).
conclusionThere was a clear seasonal variation in depression prevalence among stroke patients. Vitamin D status plays a critical mediating role in the relationship between season and post-stroke depression.
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