ArticleBMC genomics2018
Dissection of the molecular bases of genotype x environment interactions: a study of phenotypic plasticity of Saccharomyces cerevisiae in grape juices.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Predictive models of the genetic bases underlying budding yeast fitness in multiple environments.NAR genomics and bioinformatics · 2026Article
- From Oak to Wine: Evolution, Admixture, and Adaptation of California and British Columbia Saccharomyces Cerevisiae Wine Strains.Genome biology and evolution · 2026Article
- Predictive models of the genetic bases underlying budding yeast fitness in multiple environments.bioRxiv : the preprint server for biology · 2025Article
- Enhancing recombinant protein production through Cre-loxP mediated chromosomal rearrangement evolution in Kluyveromyces marxianus.Communications biology · 2025Article
- The Role of Phenotypic Plasticity and Within-Environment Trait Variability in the Assembly of the Nectar Microbiome and Plant-Microbe-Animal Interactions.Ecology and evolution · 2025Review
- Endo metabolomic profiling ofFrontiers in microbiology · 2023Article
- Genome-wide association study identifies a gene responsible for temperature-dependent rice germination.Nature communications · 2022Article
- Genomic Adaptations ofMicroorganisms · 2022Review
- Epigenetic variation: A major player in facilitating plant fitness under changing environmental conditions.Frontiers in cell and developmental biology · 2022Review
- Dissection of quantitative trait loci in the Lachancea waltii yeast species highlights major hotspots.G3 (Bethesda, Md.) · 2021Article
- QTL mapping: an innovative method for investigating the genetic determinism of yeast-bacteria interactions in wine.Applied microbiology and biotechnology · 2021Article
- Marker Assisted Selection of Malic-ConsumingJournal of fungi (Basel, Switzerland) · 2021Article
- Reciprocal hemizygosity analysis reveals that the Saccharomyces cerevisiae CGI121 gene affects lag time duration in synthetic grape must.G3 (Bethesda, Md.) · 2021Article
- Flor Yeasts Rewire the Central Carbon Metabolism During Wine Alcoholic Fermentation.Frontiers in fungal biology · 2021Article
- Article
- Natural allelic variations of Saccharomyces cerevisiae impact stuck fermentation due to the combined effect of ethanol and temperature; a QTL-mapping study.BMC genomics · 2019Article
- Quantitative Trait Nucleotides Impacting the Technological Performances of IndustrialFrontiers in genetics · 2019Article
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8 authors.
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Abstract
backgroundThe ability of a genotype to produce different phenotypes according to its surrounding environment is known as phenotypic plasticity. Within different individuals of the same species, phenotypic plasticity can vary greatly. This contrasting response is caused by gene-by-environment interactions (GxE). Understanding GxE interactions is particularly important in agronomy, since selected breeds and varieties may have divergent phenotypes according to their growing environment. Industrial microbes such as Saccharomyces cerevisiae are also faced with a large range of fermentation conditions that affect their technological properties. Finding the molecular determinism of such variations is a critical task for better understanding the genetic bases of phenotypic plasticity and can also be helpful in order to improve breeding methods.
resultsIn this study we implemented a QTL mapping program using two independent cross (~ 100 progeny) in order to investigate the molecular basis of yeast phenotypic response in a wine fermentation context. Thanks to whole genome sequencing approaches, both crosses were genotyped, providing saturated genetic maps of thousands of markers. Linkage analyses allowed the detection of 78 QTLs including 21 with significant interaction with the environmental conditions. Molecular dissection of a major QTL demonstrated that the sulfite pump Ssu1p has a pleiotropic effect and impacts the phenotypic plasticity of several traits.
conclusionsThe detection of QTLs and their interactions with environment emphasizes the complexity of yeast industrial traits. The validation of the interaction of SSU1 allelic variants with the nature of the fermented juice increases knowledge about the impact of the sulfite pump during fermentation. All together these results pave the way for exploiting and deciphering the genetic determinism of phenotypic plasticity.
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