ArticleJournal of neuroengineering and rehabilitation2018
Impact of antagonistic muscle co-contraction on in vivo knee contact forces.
Article in Journal of neuroengineering and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Effects of instrument-assisted soft tissue mobilization combined with exercise on knee joint muscle activity during walking in patients with moderate knee osteoarthritis: A randomized controlled clinical trial.Scientific reports · 2025Trial
- The effects of Tai Chi on clinical outcomes and gait biomechanics in knee osteoarthritis patients: a pilot randomized controlled trial.Scientific reports · 2025Trial
- Foot Progression Angle Modulates Knee Loading During Walking in Individuals with Flexible Flatfoot.Annals of biomedical engineering · 2026Article
- Preoperative Anxiety and Depression Are Associated with Lateral Compartment Osteoarthritis Progression After Medial Unicompartmental Knee Arthroplasty: A Retrospective Observational Cohort Study.Journal of clinical medicine · 2026Article
- Associations of muscle coactivation patterns with gait, muscle strength, and symptoms across different stages of knee osteoarthritis.Knee surgery & related research · 2026Article
- Ergonomic posture breaks enhance solute transport in cartilage: a musculoskeletal-poroelastic modelling study.European journal of applied physiology · 2026Article
- Exploring the effect of different neural strategies on the knee joint contact forces during walking in adults.Scientific reports · 2026Article
- Balanced Medial Collateral Ligament (MCL) Length, Not Intrinsic Laxity, Governs Load Sharing and Kinematics in Mechanically Aligned Posterior-Stabilized TKA.Annals of biomedical engineering · 2026Article
- Interpretable Machine Learning on Simulation-Derived Biomechanical Features for Hamstrings-Quadriceps Imbalance Detection in Running.Sports (Basel, Switzerland) · 2025Article
- Associations of quadriceps activation during step-up with pain during movement and physical function in people with knee osteoarthritis.Clinical biomechanics (Bristol, Avon) · 2025Article
- Loading of the artificial knee during early rehabilitation and physiotherapy : an in vivo study.Bone & joint open · 2025Article
- Relationship Between Lower-Extremity Co-Contraction and Jerk During Gait.Sensors (Basel, Switzerland) · 2025Article
- Center of Pressure of Medial Knee Contact Force Predicts Future Transition Risk of Knee Surgery in Patients with Knee Osteoarthritis.Annals of biomedical engineering · 2025Article
- Comparison of Lower Limb Joint Reaction Forces in Patients with Cerebral Palsy and Typically Developing Individuals.Medicina (Kaunas, Lithuania) · 2025Article
- Assessment of synergy-assisted EMG-driven NMSK model for upper limb muscle activation prediction in cross-country sit-skiing double poling.Frontiers in bioengineering and biotechnology · 2025Article
- Muscle activation patterns and gait changes in unilateral knee osteoarthritis patients: a comparative study with healthy controls.Clinical rheumatology · 2024Article
- Impact of the external knee flexion moment on patello-femoral loading derived fromFrontiers in bioengineering and biotechnology · 2024Article
- Association of mechanical temporal summation of pain with muscle co-contraction during walking in people with knee osteoarthritis.Clinical biomechanics (Bristol, Avon) · 2023Article
- Lower-limb internal loading and potential consequences for fracture healing.Frontiers in bioengineering and biotechnology · 2023Article
- Periarticular muscle status affectsFrontiers in bioengineering and biotechnology · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe onset and progression of osteoarthritis, but also the wear and loosening of the components of an artificial joint, are commonly associated with mechanical overloading of the structures. Knowledge of the mechanical forces acting at the joints, together with an understanding of the key factors that can alter them, are critical to develop effective treatments for restoring joint function. While static anatomy is usually the clinical focus, less is known about the impact of dynamic factors, such as individual muscle recruitment, on joint contact forces.
methodsIn this study, instrumented knee implants provided accurate in vivo tibio-femoral contact forces in a unique cohort of 9 patients, which were used as input for subject specific musculoskeletal models, to quantify the individual muscle forces during walking and stair negotiation.
resultsEven between patients with a very similar self-selected gait speed, the total tibio-femoral peak forces varied 1.7-fold, but had only weak correlation with static alignment (varus/valgus). In some patients, muscle co-contraction of quadriceps and gastrocnemii during walking added up to 1 bodyweight (~ 50%) to the peak tibio-femoral contact force during late stance. The greatest impact of co-contraction was observed in the late stance phase of stair ascent, with an increase of the peak tibio-femoral contact force by up to 1.7 bodyweight (66%).
conclusionsTreatment of diseased and failed joints should therefore not only be restricted to anatomical reconstruction of static limb axes alignment. The dynamic activation of muscles, as a key modifier of lower limb biomechanics, should also be taken into account and thus also represents a promising target for restoring function, patient mobility, and preventing future joint failure.
trial registrationGerman Clinical Trials Register: ID: DRKS00000606 , date: 05.11.2010.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.