Trial reportAmerican journal of respiratory and critical care medicine2019
Preventive Inhalation of Hypertonic Saline in Infants with Cystic Fibrosis (PRESIS). A Randomized, Double-Blind, Controlled Study.
Abstract readComparative StudyRandomized Controlled Trial
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
10.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Nebulised hypertonic saline for cystic fibrosis.The Cochrane database of systematic reviews · 2023Pooled it
- Hypertonic saline in people with cystic fibrosis: review of comparative studies and clinical practice.Italian journal of pediatrics · 2021Pooled it
- Effects of Lumacaftor/Ivacaftor on Cystic Fibrosis Disease Progression in Children 2 through 5 Years of Age Homozygous forAnnals of the American Thoracic Society · 2023Trial
- Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 Through 11 Years of Age with Cystic Fibrosis Heterozygous forAmerican journal of respiratory and critical care medicine · 2022Trial
- Infant Lung Function in Cystic Fibrosis: A Real-World Study.Pediatric pulmonology · 2025Article
- The established chest MRI score for cystic fibrosis can be applied to contrast agent-free matrix pencil decomposition functional MRI: a multireader analysis.Frontiers in medicine · 2025Article
- Evidence-based management guidelines for noncystic fibrosis bronchiectasis in children and adolescents.Clinical and experimental pediatrics · 2024Article
- Impact of elexacaftor/tezacaftor/ivacaftor therapy on lung clearance index and magnetic resonance imaging in children with cystic fibrosis and one or twoThe European respiratory journal · 2024Observational
- Cystic fibrosis.Nature reviews. Disease primers · 2024Review
- Multiple-breath washout to detect lung disease in patients with inborn errors of immunity.ERJ open research · 2024Article
- Automated lung segmentation on chest MRI in children with cystic fibrosis.Frontiers in medicine · 2024Article
- Advancing the pipeline of cystic fibrosis clinical trials: a new roadmap with a global trial network perspective.The Lancet. Respiratory medicine · 2023Review
- Nationwide lung function monitoring from infancy in newborn-screened children with cystic fibrosis.ERJ open research · 2023Article
- A novel thiol-saccharide mucolytic for the treatment of muco-obstructive lung diseases.The European respiratory journal · 2023Article
- Magnetic resonance imaging detects onset and association with lung disease severity of bronchial artery dilatation in cystic fibrosis.ERJ open research · 2023Article
- Longitudinal lung clearance index and association with structural lung damage in children with cystic fibrosis.Thorax · 2023Article
- Expert group recommendation on inhaled mucoactive drugs in pediatric respiratory diseases: an Indian perspective.Frontiers in pediatrics · 2023Review
- Comment on "Efficacy of hypertonic saline versus isotonic saline among children with cystic fibrosis: A systematic review and meta-analysis".Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2023Article
- Efficacy of hypertonic saline versus isotonic saline among children with cystic fibrosis: A systematic review and meta-analysis.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2023Review
- Long-term effects of lumacaftor/ivacaftor on paranasal sinus abnormalities in children with cystic fibrosis detected with magnetic resonance imaging.Frontiers in pharmacology · 2023Article
Corrections and comments
- Commented on by
Authors and funding
15 authors at 7 institutions in 2 countries.
Mirjam Stahl1 Department of Translational Pulmonology.ORCID 0000-0001-6941-8315
Mark O Wielpütz4 Department of Diagnostic and Interventional Radiology, University of Heidelberg, Heidelberg, Germany.
Isabell Ricklefs6 Division of Pediatric Allergology and Pneumology, Department of Pediatrics, Medical University of Lübeck, Lübeck, Germany.
Christian Dopfer8 Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Sandra Barth10 Department of Pediatrics, Justus-Liebig-University Giessen, Giessen, Germany.
Anne Schlegtendal12 Department of Pediatric Pulmonology, University Children's Hospital of Ruhr University Bochum at St. Josef-Hospital, Bochum, Germany.
Simon Y Graeber1 Department of Translational Pulmonology.
Olaf Sommerburg2 Division of Pediatric Pulmonology and Allergy and Cystic Fibrosis Center, Department of Pediatrics, and.
Gesa Diekmann6 Division of Pediatric Allergology and Pneumology, Department of Pediatrics, Medical University of Lübeck, Lübeck, Germany.
Johannes Hüsing15 Coordination Center for Clinical Trials, Heidelberg University Hospital, Heidelberg, Germany.
Cordula Koerner-Rettberg12 Department of Pediatric Pulmonology, University Children's Hospital of Ruhr University Bochum at St. Josef-Hospital, Bochum, Germany.
Lutz Nährlich10 Department of Pediatrics, Justus-Liebig-University Giessen, Giessen, Germany.
Anna-Maria Dittrich8 Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Matthias V Kopp6 Division of Pediatric Allergology and Pneumology, Department of Pediatrics, Medical University of Lübeck, Lübeck, Germany.
Marcus A Mall1 Department of Translational Pulmonology.ORCID 0000-0002-4057-2199
Cystic Fibrosis Foundation · USGerman Center for Lung Research · DEJustus-Liebig-Universität Gießen · DEMedizinische Hochschule Hannover · DESt. Josef-Hospital · DEGerman Cancer Research Center · DEHeidelberg University · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Administration, InhalationCystic FibrosisIsotonic SolutionsSaline Solution, HypertonicChild, PreschoolDouble-Blind MethodFemaleHumansInfantInfant, NewbornMaleIsotonic SolutionsSaline Solution, Hypertoniccystic fibrosislung clearance indexlung diseasemagnetic resonance imagingpreventive therapy
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.