Evidence map›Paper›PMID 30408777›Full record

ArticleJournal of innate immunity2019

TLR Activation Alters Bone Marrow-Derived Macrophage Differentiation.

Gertrude O Oppong-Nonterah, Omar Lakhdari, Asami Yamamura, Hal M Hoffman, Lawrence S Prince

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of innate immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. A Leak in the Dike.Journal of innate immunity · 2020
    Article
  4. Catch Me if You Can or Actors on the Run.Journal of innate immunity · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gertrude O Oppong-NonterahDepartment of Pediatrics, University of California San Diego, Rady Children's Hospital, San Diego, California, USA.
Omar LakhdariDepartment of Pediatrics, University of California San Diego, Rady Children's Hospital, San Diego, California, USA.
Asami YamamuraDepartment of Pediatrics, University of California San Diego, Rady Children's Hospital, San Diego, California, USA.
Hal M HoffmanDepartment of Pediatrics, University of California San Diego, Rady Children's Hospital, San Diego, California, USA.
Lawrence S PrinceDepartment of Pediatrics, University of California San Diego, Rady Children's Hospital, San Diego, California, USA, lprinceucsd@gmail.com.
University of California, San Diego · USRady Children's Hospital-San Diego · US

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4M
FGF-10 Expression in a Fetal Mouse Lung Model of Bronchopulmonary DysplasiaR01HL086324 · NHLBI · VANDERBILT UNIVERSITY · PI PRINCE, LAWRENCE S · 2008 to 2017
$3.7M
Role of Fetal Lung Macrophages in Broncopulmonary DysplasiaR01HL097195 · NHLBI · VANDERBILT UNIVERSITY · PI BLACKWELL, TIMOTHY S., PRINCE, LAWRENCE S · 2009 to 2013
$2.6M
Transcriptional Control of Lung Macrophage DevelopmentR01HL126703 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOFFMAN, HAROLD M, PRINCE, LAWRENCE S · 2015 to 2018
$1.6M
NHLBI NIH HHS R01 HL086324NHLBI NIH HHS R01 HL097195NHLBI NIH HHS R01 HL126703NIAID NIH HHS P30 AI036214
6 · The paper itself

Abstract

Early exposure to inflammatory signals may have a lasting impact on immune function. Present throughout embryogenesis, macrophages are key cells providing innate immune protection to the developing fetus and newborn. Here, we have used an established model of macrophage development to test how early inflammatory signals can impact cellular differentiation and function. Bone marrow-derived macrophages were treated with Escherichia coli lipopolysaccharide (LPS) 2 days after initial isolation and culture. LPS treatment during this early stage of differentiation decreased the expression of CSF1R and increased that of the mature macrophage marker F4/80. These early changes in macrophage differentiation were also measured in cells from mice lacking IKKβ, but the change in CSF1R expression after LPS treatment was blocked with MAPK inhibition. LPS-induced changes in macrophage marker expression persisted following LPS removal, suggesting that early inflammatory activation could induce a lasting developmental impact. Early LPS exposure inhibited macrophage phagocytosis of labeled E. coli while LPS had no effect on fully differentiated macrophages. Our data demonstrate that early inflammatory exposure to a microbial stimulus induce lasting phenotypic changes in macrophages.

Indexed as

Cell DifferentiationMacrophage ActivationMacrophagesAnimalsAntigens, DifferentiationCalcium-Binding ProteinsEscherichia coliI-kappa B KinaseImmunity, InnateLipopolysaccharidesMiceMitogen-Activated Protein KinasesPhagocytosisReceptors, G-Protein-CoupledReceptors, Granulocyte-Macrophage Colony-Stimulating FactorSignal TransductionAdgre1 protein, mouseAntigens, DifferentiationCalcium-Binding ProteinsCsf1r protein, mouseI-kappa B KinaseLipopolysaccharidesMitogen-Activated Protein KinasesReceptors, G-Protein-CoupledReceptors, Granulocyte-Macrophage Colony-Stimulating FactorToll-Like ReceptorsInnate immunityLipopolysaccharideMacrophage progenitorsPhagocytosis

Identifiers

PMID30408777
PMCPMC6296861
OpenAlexW2900350060

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.