ArticleBone2019
Aberrantly elevated Wnt signaling is responsible for cementum overgrowth and dental ankylosis.
Article in Bone, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07587567 (Determination of Risk Factors for Eruption Disorders in the Primary and Permanent Dentition), which is not on this map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Determination of Risk Factors for Eruption Disorders in the Primary and Permanent Dentition
Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Loss of PTH 1 receptor signaling in periodontal cells drives cementum dysfunction and molar ankylosis in mice.Bone research · 2026Article
- Roles of Wnt signaling pathway in cementum formation, cementum regeneration, and cementocyte function.Journal of Zhejiang University. Science. B · 2026Review
- Prevalence, extent and surrounding bone density of ankylosed impacted maxillary canines.BMC oral health · 2026Article
- Bioengineered mPCL scaffolds with LiCl-stimulated hPDLCs cell sheets for enhanced periodontal regeneration.Clinical oral investigations · 2025Article
- Permanent first molar eruption failure in children: leading signs for early diagnosis.Progress in orthodontics · 2025Observational
- Effects of ECM Components on Periodontal Ligament Stem Cell Differentiation Under Conditions of Disruption of Wnt and TGF-β Signaling Pathways.Journal of functional biomaterials · 2025Article
- Wnt/β-catenin Promotes Cementum Apposition in Periodontal Regeneration.Journal of dental research · 2025Article
- Abnormal dental follicle cells: A crucial determinant in tooth eruption disorders (Review).Molecular medicine reports · 2024Review
- FGF signaling modulates mechanotransduction/WNT signaling in progenitors during tooth root development.Bone research · 2024Article
- Functional defects in cementoblasts with disrupted bone sialoprotein functional domains, in vitro.Bone · 2024Article
- LITTIP/Lgr6/HnRNPK complex regulates cementogenesis via Wnt signaling.International journal of oral science · 2023Article
- The LRP5 high-bone-mass mutation causes alveolar bone accrual with minor craniofacial alteration.Journal of periodontal research · 2023Article
- Wnt/β-Catenin Signaling in Craniomaxillofacial Osteocytes.Current osteoporosis reports · 2023Review
- Between a rock and a hard place: Regulation of mineralization in the periodontium.Genesis (New York, N.Y. : 2000) · 2022Review
- Platelet-derived growth factor-BB regenerates functional periodontal ligament in the tooth replantation.Scientific reports · 2022Article
- The osteocyte as a signaling cell.Physiological reviews · 2022Review
- Molecular Basis for Craniofacial Phenotypes Caused by Sclerostin Deletion.Journal of dental research · 2021Article
- The Role of Wnt Signaling in Postnatal Tooth Root Development.Frontiers in dental medicine · 2021Article
- Although Anatomically Micrometers Apart: Human Periodontal Ligament Cells Are Slightly More Active in Bone Remodeling Than Alveolar Bone Derived Cells.Frontiers in cell and developmental biology · 2021Article
- Bioactivating a bone substitute accelerates graft incorporation in a murine model of vertical ridge augmentation.Dental materials : official publication of the Academy of Dental Materials · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
Vertebrate teeth are attached to the jawbones using a variety of methods but in mammals, a fibrous connection is the norm. This fibrous periodontal ligament (PDL) allows teeth to move in the jawbones in response to natural eruptive forces, mastication, and orthodontic tooth movement. In some disease states the PDL either calcifies or is replaced by a mineralized tissue and the result is ankylosis, where the tooth is fused to the alveolar bone. To understand how the PDL maintains this fibrous state, we examined a strain of mice in which tooth movement is arrested. Daβcat
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.