Evidence map›Paper›PMID 30408544›Full record

ArticleBiochimica et biophysica acta. Molecular cell research2019

Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers.

Christopher J Penny, Kristin Vassileva, Archana Jha, Yu Yuan, Xavier Chee, Elizabeth Yates, Michela Mazzon, Bethan S Kilpatrick, Shmuel Muallem, Mark Marsh and 2 more

Open access · greenAbstract read
In one paragraph

Article in Biochimica et biophysica acta. Molecular cell research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 75 citations in OpenAlex.

  1. Review
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  6. Article
  7. Plasticity of the selectivity filter is essential for permeation in lysosomal TPC2 channels.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Review
  9. Convergent activation of CaScience signaling · 2023
    Article
  10. Unveiling the impact of lysosomal ion channels: balancing ion signaling and disease pathogenesis.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Two-pore channels: going with the flows.Biochemical Society transactions · 2022
    Article
  15. Review
  16. Review
  17. NAADP-binding proteins find their identity.Trends in biochemical sciences · 2022
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Christopher J PennyDepartment of Cell and Developmental Biology, University College London, London, UK.
Kristin VassilevaDepartment of Cell and Developmental Biology, University College London, London, UK; MRC Laboratory for Molecular Cell Biology, University College London, London, UK.
Archana JhaEpithelial Signaling and Transport Section, National Institute of Dental Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Yu YuanDepartment of Cell and Developmental Biology, University College London, London, UK.
Xavier CheeDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Elizabeth YatesDepartment of Cell and Developmental Biology, University College London, London, UK.
Michela MazzonMRC Laboratory for Molecular Cell Biology, University College London, London, UK.
Bethan S KilpatrickDepartment of Cell and Developmental Biology, University College London, London, UK.
Shmuel MuallemEpithelial Signaling and Transport Section, National Institute of Dental Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Mark MarshMRC Laboratory for Molecular Cell Biology, University College London, London, UK.
Taufiq RahmanDepartment of Pharmacology, University of Cambridge, Cambridge, UK. Electronic address: mtur2@cam.ac.uk.
Sandip PatelDepartment of Cell and Developmental Biology, University College London, London, UK. Electronic address: patel.s@ucl.ac.uk.
University College London · GBMRC Laboratory for Molecular Cell Biology · GBNational Institutes of Health · USUniversity of Cambridge · GBUniversity College Hospital · GB

Funding

Ca2+ signaling and HCO3- secretion by exocrine glandsZIADE000735 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI MUALLEM, SHMUEL · 2010 to 2025
$43.1M
Biotechnology and Biological Sciences Research Council BB/G013721/1Medical Research Council MC_UU_00012/1Medical Research Council MC_UU_12018/1Medical Research Council MR/K015826/1Medical Research Council MR/M02492X/1Parkinson's UK H-1202Parkinson's UK K-1107Parkinson's UK K-1412
6 · The paper itself

Abstract

Two-pore channels (TPCs) are Ca

Indexed as

AnimalsAntiviral AgentsCalcium ChannelsDrug EvaluationEbolavirusHEK293 CellsHumansLysosomesPhosphatidylinositol PhosphatesSea UrchinsVirus InternalizationAntiviral AgentsCalcium Channelsphosphatidylinositol 3,5-diphosphatePhosphatidylinositol PhosphatesTPCN2 protein, humanCa(2+)Ebola virusLysosomesNAADPTPC2Virtual screening

Identifiers

PMID30408544
PMCPMC7114365
OpenAlexW2899671967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.