ArticleNeuron2018
Noninvasive Ultrasonic Drug Uncaging Maps Whole-Brain Functional Networks.
Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 98 citations in OpenAlex.
- Ultrasound-Assisted multimodal neuromodulation via nanosystems.Journal of nanobiotechnology · 2026Review
- Illuminating consciousness.Frontiers in psychology · 2026Review
- Acoustically activatable liposomes as a translational nanotechnology for site-targeted drug delivery and noninvasive neuromodulation.Nature nanotechnology · 2025Article
- Developing algorithmic psychiatry via multi-level spanning computational models.Cell reports. Medicine · 2025Review
- Article
- What can neuroimaging of neuromodulation reveal about the basis of circuit therapies for psychiatry?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- A review of temporal interference, nanoparticles, ultrasound, gene therapy, and designer receptors for Parkinson disease.NPJ Parkinson's disease · 2024Review
- Review
- Practical Targeting Errors During Optically Tracked Transcranial Focused Ultrasound Using MR-ARFI and Array- Based Steering.IEEE transactions on bio-medical engineering · 2024Article
- Remotely controlled drug release in deep brain regions of non-human primates.Journal of controlled release : official journal of the Controlled Release Society · 2024Article
- Nanoencapsulation of general anaesthetics.Nanoscale advances · 2024Review
- Device for Multifocal Delivery of Ultrasound Into Deep Brain Regions in Humans.IEEE transactions on bio-medical engineering · 2024Article
- Sex dependence of opioid-mediated responses to subanesthetic ketamine in rats.Nature communications · 2024Article
- Controlled ultrasonic interventions through the human skull.Frontiers in human neuroscience · 2024Article
- Targeted drug release from stable and safe ultrasound-sensitive nanocarriers.Frontiers in molecular biosciences · 2024Article
- Nanoparticle-based optical interfaces for retinal neuromodulation: a review.Frontiers in cellular neuroscience · 2024Review
- Current Status and Future Strategies for Advancing Functional Circuit MappingThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Acoustomechanically activatable liposomes for ultrasonic drug uncaging.bioRxiv : the preprint server for biology · 2023Article
- Ketamine evoked disruption of entorhinal and hippocampal spatial maps.Nature communications · 2023Article
- Physical Characterization to Improve Scalability and Potential of Anesthetic-Loaded Nanodroplets.Pharmaceutics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Being able to noninvasively modulate brain activity, where and when an experimenter desires, with an immediate path toward human translation is a long-standing goal for neuroscience. To enable robust perturbation of brain activity while leveraging the ability of focused ultrasound to deliver energy to any point of the brain noninvasively, we have developed biocompatible and clinically translatable nanoparticles that allow ultrasound-induced uncaging of neuromodulatory drugs. Utilizing the anesthetic propofol, together with electrophysiological and imaging assays, we show that the neuromodulatory effect of ultrasonic drug uncaging is limited spatially and temporally by the size of the ultrasound focus, the sonication timing, and the pharmacokinetics of the uncaged drug. Moreover, we see secondary effects in brain regions anatomically distinct from and functionally connected to the sonicated region, indicating that ultrasonic drug uncaging could noninvasively map the changes in functional network connectivity associated with pharmacologic action at a particular brain target.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.