ArticlePloS one2018
Dietary fiber sources and non-starch polysaccharide-degrading enzymes modify mucin expression and the immune profile of the swine ileum.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Animal organoids as models for integrated One Health research.One health (Amsterdam, Netherlands) · 2026Review
- Nutritional Composition and Digestibility of Corn Ethanol Coproducts in Swine Feed: A Systematic Literature Review.Animals : an open access journal from MDPI · 2026Review
- Construction of a Duck Intestinal Organoid Culture System: From Crypt Isolation to Medium Optimization.Animals : an open access journal from MDPI · 2025Article
- β-mannanase supplemented in diets saved 85 to 100 kcal of metabolizable energy/kg, supporting growth performance and improving nutrient digestibility in grower pigs.Scientific reports · 2023Article
- Fecal microbial and metabolic characteristics of swine from birth to market.Frontiers in microbiology · 2023Article
- Identification of Independent and Shared Metabolic Responses to High-Fiber and Antibiotic Treatments in Fecal Metabolome of Grow-Finish Pigs.Metabolites · 2022Article
- Decreased nutrient digestibility due to viscosity is independent of the amount of dietary fibre fed to growing pigs.The British journal of nutrition · 2022Article
- Farm and Companion Animal Organoid Models in Translational Research: A Powerful Tool to Bridge the Gap Between Mice and Humans.Frontiers in medical technology · 2022Review
- Acute infection withFrontiers in cellular and infection microbiology · 2022Article
- Dietary zinc restriction affects the expression of genes related to immunity and stress response in the small intestine of pigs.Journal of nutritional science · 2022Article
- The Probiotic Properties of Lactic Acid Bacteria and Their Applications in Animal Husbandry.Current microbiology · 2021Review
- Effect of dietary crude protein level on growth performance, blood characteristics, and indicators of intestinal health in weanling pigs.Journal of animal science · 2021Article
- Measures Matter-Determining the True Nutri-Physiological Value of Feed Ingredients for Swine.Animals : an open access journal from MDPI · 2021Review
- Organoids: a promising new in vitro platform in livestock and veterinary research.Veterinary research · 2021Review
- Intestinal organoids in farm animals.Veterinary research · 2021Review
- Comparative Effects of Compound Enzyme and Antibiotics on Growth Performance, Nutrient Digestibility, Blood Biochemical Index, and Intestinal Health in Weaned Pigs.Frontiers in microbiology · 2021Article
- Swine gut microbiota and its interaction with host nutrient metabolism.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2020Review
- Growth performance, nutrient digestibility, and fecal microbial composition of weaned pigs fed multi-enzyme supplemented diets.Journal of animal science · 2020Article
- Analysis of Gastrointestinal Responses Revealed Both Shared and Specific Targets of Zinc Oxide and Carbadox in Weaned Pigs.Antibiotics (Basel, Switzerland) · 2020Article
- Effect of phytase on nutrient digestibility and expression of intestinal tight junction and nutrient transporter genes in pigs.Journal of animal science · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to their complex chemical and physical properties, the effects and mechanisms of action of natural sources of dietary fiber on the intestine are unclear. Pigs are commonly fed high-fiber diets to reduce production costs and non-starch polysaccharide (NSP)-degrading enzymes have been used to increase fiber digestibility. We evaluated the expression of mucin 2 (MUC2), presence of goblet cells, and ileal immune profile of pigs housed individually for 28 days and fed either a low fiber diet based on corn-soybean meal (CSB, n = 9), or two high fiber diets formulated adding 40% corn distillers' dried grains with solubles (DDGS, n = 9) or 30% wheat middlings (WM, n = 9) to CSB-based diet. Pigs were also fed those diets supplemented with a NSP enzymes mix (E) of xylanase, β-glucanase, mannanase, and galactosidase (n = 8, 10, and 9 for CSB+E, DDGS+E and WM+E, respectively). Feeding DDGS and WM diets increased ileal MUC2 expression compared with CSB diet, and this effect was reversed by the addition of enzymes. There were no differences in abundance of goblet cells among treatments. In general, enzyme supplementation increased gene expression and concentrations of IL-1β, and reduced the concentrations of IL-4, IL-17A and IL-11. The effects of diet-induced cytokines on modulating intestinal MUC2 were assessed in vitro by treating mouse and swine enteroids with 1 ng/ml of IL-4 and IL-1β. In accordance with previous studies, treatment with Il-4 induced Muc2 and expansion of goblet cells in mouse enteroids. However, swine enteroids did not change MUC2 expression or number of goblet cells when treated with IL-4 or IL-1β. Our results suggest that mucin and immune profile are regulated by diet in the swine intestine, but by mechanisms different to mouse, emphasizing the need for using appropriate models to study responses to dietary fiber in swine.
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