Evidence map›Paper›PMID 30408008›Full record

ArticleThe Pediatric infectious disease journal2018

Second-trimester Ultrasound and Neuropathologic Findings in Congenital Zika Virus Infection.

Cheng-Ying Ho, Nicolas Castillo, Liliana Encinales, Alexandra Porras, Alejandro Rico Mendoza, Rebecca Lynch, Amy Nemirovsky, Grace Mantus, Roberta L DeBiasi, Jeffrey M Bethony and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Pediatric infectious disease journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Cheng-Ying HoFrom the Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland.
Nicolas CastilloDepartment of Maternal Fetal Health.
Liliana EncinalesDepartment of Medicine, Allied Research Society LLC, Baranquilla, Atlántico, Colombia.
Alexandra PorrasGrupo de Medicina Comunitaria, Universidad El Bosque, Bogotá, Colombia.
Alejandro Rico MendozaGrupo de Medicina Comunitaria, Universidad El Bosque, Bogotá, Colombia.
Rebecca LynchDepartment of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, District of Columbia.
Amy NemirovskyFrom the Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland.
Grace MantusDepartment of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, District of Columbia.
Roberta L DeBiasiDivision of Pediatric Infectious Diseases, Children's National Health System, Washington District of Columbia.
Jeffrey M BethonyDepartment of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, District of Columbia.
Gary L SimonDepartment of Medicine, The George Washington University, Washington, District of Columbia.
Aileen Y ChangDepartment of Medicine, The George Washington University, Washington, District of Columbia.
George Washington University · USUniversidad El Bosque · COUniversity of Maryland, Baltimore · US

Funding

Clinical and Translational Science Institute at Childrens NationalUL1TR001876 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI BELL, MICHAEL J · 2016 to 2021
$25.6M
Modeling Zika virus pathogenesis and potential intervention during neural development using a human brain organoid systemU19AI131130 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI MING, GUO-LI · 2017 to 2021
$7.7M
Functional roles of genetic risk factors for brain disorders in neurogenesis and neurodevelopmentR35NS097370 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MING, GUO-LI · 2017 to 2024
$6.7M
Circuitry mechanisms underlying normal and aberrant adult hippocampal neurogenesisR01MH105128 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MING, GUO-LI · 2014 to 2018
$2.0M
Clinical and Translational Science Institute at Childrens National-Mentored Career Development CoreKL2TR001877 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI LUBAN, NAOMI L · 2016 to 2020
$2.0M
NCATS NIH HHS KL2 TR001877NCATS NIH HHS UL1 TR001876NIAID NIH HHS U19 AI131130NIMH NIH HHS R01 MH105128NINDS NIH HHS R35 NS097370
6 · The paper itself

Abstract

Zika virus is a mosquito-borne virus that causes congenital Zika syndrome, characterized by microcephaly and other fetal brain anomalies. This case report presents a case of Zika virus-related fetal brain anomalies including pathologic evidence of cerebral neuronal apoptosis and macrophage infiltrates and intracerebral calcification, ventriculomegaly and corpus callosum dysgenesis detected by ultrasound at 18 weeks of pregnancy.

Indexed as

AdultBrainFemaleHumansNervous System DiseasesPregnancyPregnancy Complications, InfectiousPregnancy Trimester, SecondUltrasonography, PrenatalZika VirusZika Virus Infection

Identifiers

PMID30408008
PMCPMC6233735
OpenAlexW2799839276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.