Evidence map›Paper›PMID 30407748›Full record

ArticleJournal of cellular and molecular medicine2019

Gestational age-dependent gene expression profiling of ATP-binding cassette transporters in the healthy human placenta.

Guinever E Imperio, Mohsen Javam, Phetcharawan Lye, Andrea Constantinof, Caroline E Dunk, Fernando M Reis, Stephen J Lye, William Gibb, Stephen G Matthews, Tania Maria Ortiga-Carvalho and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

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  13. Phenomics (Cham, Switzerland) · 2021
    Article
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  15. Pleiotropic Roles of ABC Transporters in Breast Cancer.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Guinever E ImperioDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
Mohsen JavamDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
Phetcharawan LyeDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
Andrea ConstantinofDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
Caroline E DunkLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID 0000-0002-4146-099X
Fernando M ReisDivision of Human Reproduction, Department of Obstetrics and Gynecology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Stephen J LyeDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
William GibbDepartment of Obstetrics & Gynecology and Department of Cellular & Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Stephen G MatthewsDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
Tania Maria Ortiga-CarvalhoLaboratory of Translational Endocrinology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Enrrico BloiseDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-0275-8686
Mount Sinai Hospital · CAUniversidade Federal de Minas Gerais · BRUniversidade Federal do Rio de Janeiro · BRUniversity of Toronto · CAUniversity of Ottawa · CA

Funding

CIHR FDN-148368
6 · The paper itself

Abstract

The ATP-binding cassette (ABC) transporters control placental transfer of several nutrients, steroids, immunological factors, chemicals, and drugs at the maternal-fetal interface. We and others have demonstrated a gestational age-dependent expression pattern of two ABC transporters, P-glycoprotein and breast cancer resistance protein throughout pregnancy. However, no reports have comprehensively elucidated the expression pattern of all 50 ABC proteins, comparing first trimester and term human placentae. We hypothesized that placental ABC transporters are expressed in a gestational-age dependent manner in normal human pregnancy. Using the TaqMan

Indexed as

AdultATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily B, Member 1FemaleGene Expression ProfilingGestational AgeHumansNeoplasm ProteinsPlacentaPregnancyTranscriptomeTrophoblastsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily B, Member 1Neoplasm ProteinsABCA6ABC transportersgestational-agelipid transporterplacenta

Identifiers

PMID30407748
PMCPMC6307765
OpenAlexW2899937575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.