ArticleMolecular genetics & genomic medicine2018
Functional variants of the ATG7 gene promoter in acute myocardial infarction.
Article in Molecular genetics & genomic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- LncRNAiScience · 2026Article
- Natural autophagy modulators in non-communicable diseases: from autophagy mechanisms to therapeutic potential.Acta pharmacologica Sinica · 2025Review
- Insights on E1-like enzyme ATG7: functional regulation and relationships with aging-related diseases.Communications biology · 2024Review
- Protein homeostasis in the aged and diseased heart.The journal of cardiovascular aging · 2023Article
- From multi-omics approaches to personalized medicine in myocardial infarction.Frontiers in cardiovascular medicine · 2023Review
- Integrated Analysis and Validation of Autophagy-Related Genes and Immune Infiltration in Acute Myocardial Infarction.Computational and mathematical methods in medicine · 2022Article
- Association of ATG7 gene polymorphisms with microscopic polyangiitis in Chinese individuals.American journal of translational research · 2022Article
- Moments in autophagy and disease: Past and present.Molecular aspects of medicine · 2021Review
- Potential Influential Factors of In-Hospital Myocardial Reinfarction in ST-Segment Elevation Myocardial Infarction (STEMI) Patients: Finding from the Improving Care for Cardiovascular Disease in China- (CCC-) Acute Coronary Syndrome (ACS) Project.Oxidative medicine and cellular longevity · 2021Article
- Comprehensive autophagy evaluation in cardiac disease models.Cardiovascular research · 2020Review
- Functional Genetic Variant in ATG5 Gene Promoter in Acute Myocardial Infarction.Cardiology research and practice · 2020Article
- Autophagy-Related Gene 7 Polymorphisms and Cerebral Palsy in Chinese Infants.Frontiers in cellular neuroscience · 2019Article
- Functional variants of the ATG7 gene promoter in acute myocardial infarction.Molecular genetics & genomic medicine · 2018Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronary artery disease including acute myocardial infarction (AMI) is mainly caused by atherosclerosis, an inflammatory and metabolic disease. Autophagy has been demonstrated to play critical roles in lipid metabolism and inflammation. Altered autophagic activity has been reported in AMI patients. However, molecular basis for dysfunctional autophagy in AMI remains unexplained.
methodsIn this study, the promoter of the ATG7 gene, encoding a core protein for autophagy, was genetically and functionally analyzed in large cohorts of AMI patients (n = 355) and ethnic-matched healthy controls (n = 363). Related molecular mechanisms were also explored.
resultsA total of 19 DNA sequence variants (DSVs) including single-nucleotide polymorphisms (SNPs) were found in the ATG7 gene promoter. Two novel DSVs and five SNPs were only identified in AMI patients group. These DSVs and SNPs, except one SNP, significantly altered the transcriptional activity of the ATG7 gene promoter in both HEK-293 and H9c2 cells (p < 0.05). Further electrophoretic mobility shift assay revealed that the DSVs and SNPs evidently affected the binding of transcription factors.
conclusionsATG7 gene DSVs and SNPs identified in AMI patients may alter the transcriptional activity of the ATG7 gene promoter and change ATG7 level, contributing to the AMI development as a rare risk factor.
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