ArticleThe Journal of cell biology1987
Changes in the expression of alpha-fodrin during embryonic development of Xenopus laevis.
Article in The Journal of cell biology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
- Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity.Journal of cell science · 2010Article
- Presynaptic calcium channels and α3-integrins are complexed with synaptic cleft laminins, cytoskeletal elements and active zone components.Journal of neurochemistry · 2010Article
- Mechanically gated channel activity in cytoskeleton-deficient plasma membrane blebs and vesicles from Xenopus oocytes.The Journal of physiology · 2000Article
- The presynaptic calcium channel is part of a transmembrane complex linking a synaptic laminin (alpha4beta2gamma1) with non-erythroid spectrin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Establishment of the dorsal-ventral axis in Xenopus embryos coincides with the dorsal enrichment of dishevelled that is dependent on cortical rotation.The Journal of cell biology · 1999Article
- Regulation of ribosomal S6 protein kinase-p90(rsk), glycogen synthase kinase 3, and beta-catenin in early Xenopus development.Molecular and cellular biology · 1999Article
- Analysis of the signaling activities of localization mutants of beta-catenin during axis specification in Xenopus.The Journal of cell biology · 1997Article
- Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathway.The Journal of cell biology · 1997Article
- Purification of a calcium dependent ribonuclease from Xenopus laevis.Nucleic acids research · 1994Article
- Actin and actin-associated proteins in Xenopus eggs and early embryos: contribution to cytoarchitecture and gastrulation.Current topics in developmental biology · 1992Review
- Two nonallelic insulin genes in Xenopus laevis are expressed differentially during neurulation in prepancreatic embryos.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- The ultrastructure of patch-clamped membranes: a study using high voltage electron microscopy.The Journal of cell biology · 1991Article
- Fodrin as a differentiation marker. Redistributions in colonic neoplasia.The American journal of pathology · 1989Article
- Expression of the poly(A)-binding protein during development of Xenopus laevis.Molecular and cellular biology · 1989Article
- Primary structure of the brain alpha-spectrin.The Journal of cell biology · 1989Article
- Proteins regulating actin assembly in oogenesis and early embryogenesis of Xenopus laevis: gelsolin is the major cytoplasmic actin-binding protein.The Journal of cell biology · 1988Article
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4 authors.
Funding
Abstract
Fodrin (nonerythroid spectrin) and its associated proteins have been previously implicated in the establishment of specialized membrane-cytoskeletal domains in differentiating cells. Using antiserum which is monospecific for the alpha-subunit of fodrin, we demonstrate that alpha-fodrin is present in oocytes and adult tissues of Xenopus laevis. Analyses of the de novo synthesis of alpha-fodrin during embryonic development reveal that alpha-fodrin is synthesized in oocytes, but not during early development. To investigate the level of control of alpha-fodrin expression, we isolated two cDNA clones for oocyte alpha-fodrin. The oocyte cDNA clones were identified as encoding portions of alpha-fodrin based on DNA sequence analysis and on the comparison of the predicted amino acid sequence of the cDNAs with the known sequence of human erythrocyte alpha-spectrin. The Xenopus alpha-fodrin cDNAs hybridize to a transcript of approximately 9 kb on RNA blots, and probably to a single gene type on genomic DNA blots. Both RNA blot analyses and S1 nuclease protection assays with the Xenopus alpha-fodrin cDNAs demonstrate that the observed decline in the de novo synthesis of alpha-fodrin polypeptides is controlled by a dramatic decrease in the abundance of alpha-fodrin transcripts after fertilization. In contrast, levels of actin transcripts do not decrease during this period. Inasmuch as steady-state levels of alpha-fodrin transcripts rise by the neurula stage of development, these results suggest that the synthesis of alpha-fodrin polypeptides during embryonic development of Xenopus is regulated, rather than constitutive, and that the primary level of control is the steady-state abundance of mRNA.
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