Evidence map›Paper›PMID 30407395›Full record

ReviewMicromachines2016

CD-Based Microfluidics for Primary Care in Extreme Point-of-Care Settings.

Suzanne Smith, Dario Mager, Alexandra Perebikovsky, Ehsan Shamloo, David Kinahan, Rohit Mishra, Saraí M Torres Delgado, Horacio Kido, Satadal Saha, Jens Ducrée and 3 more

Abstract readReview
In one paragraph

Review in Micromachines, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Review
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Suzanne SmithCouncil for Scientific and Industrial Research, Meiring Naude Road, Brummeria, Pretoria 0001, South Africa. ssmith@csir.co.za.ORCID 0000-0002-3688-1845
Dario MagerInstitute of Microstructure Technology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen 76344, Germany. dario.mager@kit.edu.
Alexandra PerebikovskySchool of Engineering and School of Physical Sciences, University of California, Irvine, 4200 Engineering Gateway, Irvine, CA 92697-3975, USA. aperebik@gmail.com.
Ehsan ShamlooSchool of Engineering and School of Physical Sciences, University of California, Irvine, 4200 Engineering Gateway, Irvine, CA 92697-3975, USA. eshamloo@uci.edu.
David KinahanSchool of Physical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland. david.kinahan@dcu.ie.ORCID 0000-0003-1968-2016
Rohit MishraSchool of Physical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland. rohit.mishra@dcu.ie.
Saraí M Torres DelgadoSimulation Laboratory, Department of Microsystems Engineering (IMTEK), University of Freiburg, Freiburg im Breisgau 79085, Germany. sarai.torres@imtek.de.
Horacio KidoSchool of Engineering and School of Physical Sciences, University of California, Irvine, 4200 Engineering Gateway, Irvine, CA 92697-3975, USA. hkido@uci.edu.
Satadal SahaFoundation for Innovations in Health and JSV Innovations Private Limited, 44A S P Mukherjee Road, Kolkata 700026, India. drsatadal.saha@gmail.com.
Jens DucréeSchool of Physical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland. jens.ducree@dcu.ie.
Marc MadouSchool of Engineering and School of Physical Sciences, University of California, Irvine, 4200 Engineering Gateway, Irvine, CA 92697-3975, USA. mmadou@uci.edu.
Kevin LandCouncil for Scientific and Industrial Research, Meiring Naude Road, Brummeria, Pretoria 0001, South Africa. kland@csir.co.za.ORCID 0000-0002-8803-8809
Jan G KorvinkInstitute of Microstructure Technology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen 76344, Germany. jan.korvink@kit.edu.ORCID 0000-0003-4354-7295

Funding

European Research Council 290586 NMCELEuropean Union FP7-KBBE-2013-7-613908-DecathlonScience Foundation Ireland 10/CE/B1821
6 · The paper itself

Abstract

We review the utility of centrifugal microfluidic technologies applied to point-of-care diagnosis in extremely under-resourced environments. The various challenges faced in these settings are showcased, using areas in India and Africa as examples. Measures for the ability of integrated devices to effectively address point-of-care challenges are highlighted, and centrifugal, often termed CD-based microfluidic technologies, technologies are presented as a promising platform to address these challenges. We describe the advantages of centrifugal liquid handling, as well as the ability of a standard CD player to perform a number of common laboratory tests, fulfilling the role of an integrated lab-on-a-CD. Innovative centrifugal approaches for point-of-care in extremely resource-poor settings are highlighted, including sensing and detection strategies, smart power sources and biomimetic inspiration for environmental control. The evolution of centrifugal microfluidics, along with examples of commercial and advanced prototype centrifugal microfluidic systems, is presented, illustrating the success of deployment at the point-of-care. A close fit of emerging centrifugal systems to address a critical panel of tests for under-resourced clinic settings, formulated by medical experts, is demonstrated. This emphasizes the potential of centrifugal microfluidic technologies to be applied effectively to extremely challenging point-of-care scenarios and in playing a role in improving primary care in resource-limited settings across the developing world.

Indexed as

CD-based microfluidicscentrifugal microfluidicsextreme point-of-carelab-on-a-discprimary care

Identifiers

PMID30407395
PMCPMC6190444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.