Evidence map›Paper›PMID 30407299›Full record

ArticleMedicine2018

Genetic polymorphism (rs6776158) in CaSR gene is associated with risk of nephrolithiasis in Chinese population.

Hai Zhou, Huaxing Huang, Zebin You, Kamleshsingh Shadhu, Dadhija Ramlagun, Cao Qiang, Pu Li, Lezhong Qi, Yuyong Shen, Ming Zhou and 3 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Hai ZhouDepartment of Urology, Yangzhou No. 1 People's Hospital, Affiliated Hospital of Yangzhou University, Yangzhou, China.
Huaxing HuangFirst Clinical College, Nanjing Medical University, Nanjing.
Zebin YouDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Kamleshsingh ShadhuDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Dadhija RamlagunDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Cao QiangDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Pu LiDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Lezhong QiDepartment of Urology, Yangzhou No. 1 People's Hospital, Affiliated Hospital of Yangzhou University, Yangzhou, China.
Yuyong ShenDepartment of Urology, Yangzhou No. 1 People's Hospital, Affiliated Hospital of Yangzhou University, Yangzhou, China.
Ming ZhouDepartment of Urology, Yangzhou No. 1 People's Hospital, Affiliated Hospital of Yangzhou University, Yangzhou, China.
Yuming ChenDepartment of Urology, Yangzhou No. 1 People's Hospital, Affiliated Hospital of Yangzhou University, Yangzhou, China.
Shangchun FeiDepartment of Urology, Yangzhou No. 1 People's Hospital, Affiliated Hospital of Yangzhou University, Yangzhou, China.
Xiaoxiang WangDepartment of Urology, Yangzhou No. 1 People's Hospital, Affiliated Hospital of Yangzhou University, Yangzhou, China.
Yangzhou University · CNNanjing Medical University · CNJiangsu Province Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study is to find about the association between calcium-sensing receptor (CaSR) genetic variants and susceptibility to nephrolithiasis in the Chinese Han population.This hospital-based case-control study included 319 nephrolithiasis cases and 378 healthy controls subjects. Two SNPs in CaSR were genotyped using the TaqMan assay.We found that subjects carrying the G allele of rs6776158 (AG and GG) had significantly higher risk of nephrolithiasis compared to the AA genotype (P = .015 and .009, respectively).Our results indicate that rs6776158 polymorphism that might elevate the risk of nephrolithiasis in the Chinese population.

Indexed as

AdultAllelesCase-Control StudiesChinaEthnicityFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedNephrolithiasisPolymorphism, Single NucleotideReceptors, Calcium-SensingRisk FactorsCASR protein, humanReceptors, Calcium-Sensing

Identifiers

PMID30407299
PMCPMC6250535
OpenAlexW2899739668

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.