Evidence map›Paper›PMID 30406929›Full record

ArticleJournal of endocrinological investigation2019

Autoimmune thyroid diseases are more common in patients with prolactinomas: a retrospective case-control study in an Italian cohort.

T Pilli, S Cardinale, C Dalmiglio, C Secchi, N Fralassi, G Cevenini, G Di Cairano, F Maino, R Forleo, F Pacini and 1 more

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In one paragraph

Article in Journal of endocrinological investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
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  6. An update on the pathogenesis of Hashimoto's thyroiditis.Journal of endocrinological investigation · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

T PilliDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
S CardinaleDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
C DalmiglioDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
C SecchiDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
N FralassiDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
G CeveniniDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
G Di CairanoDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
F MainoDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
R ForleoDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
F PaciniDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
M G CastagnaDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy. m.g.castagna@ao-siena.toscana.it.
University of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProlactin may exert immunological effects. Over the years, a higher prevalence of autoimmune thyroid diseases (ATD) has been reported in patients with prolactinomas (PRLs) in areas with sufficient iodine intake. PURPOSE: The aim of our study was to evaluate the prevalence of ATD [Graves' disease (GD) and chronic autoimmune thyroiditis (AIT)] in a retrospective cohort of Italian patients with PRLs compared to a sex-matched control group, represented by subjects with non-functioning pituitary adenoma (NFPA) or empty sella (ES). MATERIALS AND

methodsWe enrolled 149 patients (108 F/41 M) with PRLs (110 micro/39 macro) and 143 subjects (100 F/43 M) with NFPA (n = 96, 56 micro/40 macro) or ES (n = 47), with normal serum prolactin. Neck ultrasound and thyroid function tests (anti-thyroid antibodies, TSH, FT3 and FT4) were performed in all patients.

resultsIn PRLs, median serum prolactin was significantly higher (98.3 vs. 8.9 ng/ml, p ≤ 0.0001), while age was lower (34 vs. 46 years, p ≤ 0.001) compared to controls. The prevalence of ATD was 13.4% (20/149) in PRLs (1 GD and 19 AIT) compared to 6.3% (9/143) in the controls (p = 0.042). At the multivariate analysis, serum prolactin was the only independent factor predicting ATD. Thyroid volume (12.5 ± 5.9 ml vs. 12.8 ± 10 ml, p = 0.47) and the presence of uni- or multinodular goiter (29.5% vs. 35%, p = 0.35) did not differ between PRLs and control groups.

conclusionsOur data in an area with mild iodine deficiency confirm a higher prevalence of ATD in patients with prolactinomas.

Indexed as

AdolescentAdultAgedCase-Control StudiesFemaleFollow-Up StudiesHumansItalyMaleMiddle AgedPrevalencePrognosisProlactinomaRetrospective StudiesThyroid DiseasesThyroid Function TestsAutoimmuneEmpty sellaPituitary adenomaProlactinThyroid

Identifiers

PMID30406929
OpenAlexW2899936666

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.