Evidence map›Paper›PMID 30406855›Full record

ReviewCurrent neurology and neuroscience reports2018

Untangling PTSD and TBI: Challenges and Strategies in Clinical Care and Research.

Rebecca C Hendrickson, Abigail G Schindler, Kathleen F Pagulayan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current neurology and neuroscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  5. Single-Nucleus RNA Sequencing Reveals That Gabra6Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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  20. The role of long noncoding RNA in traumatic brain injury.Neuropsychiatric disease and treatment · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Rebecca C HendricksonVISN 20 Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, 1660 S. Columbian Way, S116 MIRECC, Seattle, WA, 98108, USA. rhend@uw.edu.
Abigail G SchindlerDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, 1959 NE Pacific Street, Box 356560 Room BB1644, Seattle, WA, 98195-6560, USA.
Kathleen F PagulayanVISN 20 Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, 1660 S. Columbian Way, S116 MIRECC, Seattle, WA, 98108, USA.
VA Northwest Network · USVA Puget Sound Health Care System · US

Funding

Mild TBI and Biomarkers of NeurodegenerationI01RX000521 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI PESKIND, ELAINE R. · 2011 to 2014
–
Neural Mechanisms of Impulsivity and Attention Following Traumatic Brain InjuryIK2BX003258 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI SCHINDLER, ABIGAIL G · 2017 to 2021
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Neuroimaging and cognitive correlates of repetitive blast-related mTBIIK2CX000516 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI PAGULAYAN, KATHLEEN · 2012 to 2016
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BLRD VA IK2 BX003258CSRD VA IK2 CX000516CSRD VA IK2 CX001774RRD VA I01 RX000521RRD VA I01 RX003087
6 · The paper itself

Abstract

purpose of reviewTraumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) can result from similar injuries and can result in similar symptoms, such as problems with sleep, concentration, memory, and mood. Although PTSD and persistent sequelae due to a TBI (PST) have generally been viewed as pragmatically confounded but conceptually separable entities, we examine emerging evidence emphasizing the breadth of overlap in both clinical presentation and underlying pathophysiology between PST and PTSD. RECENT

findingsNew evidence underscores the poor specificity of symptoms to etiology and emphasizes the potential, after both physical brain injury and traumatic stress, for changes in each of the three interacting systems that coordinate the body's response to the experience or expectation of major injury-the immune, endocrine, and neuromodulatory neurotransmitter systems. A view of PTSD and PST sharing common pathophysiologic elements related to the CNS response to acute injury or threat carries important implications for research and clinical care.

Indexed as

Brain Injuries, TraumaticDiagnosis, DifferentialHumansStress Disorders, Post-TraumaticCatecholaminesNeuroinflammationPituitaryPost-traumatic stress disorder (PTSD)TraumaTraumatic brain injury (TBI)

Identifiers

PMID30406855
OpenAlexW2899638680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.