ReviewDeutsches Arzteblatt international2018
The Neurophysiology and Treatment of Motion Sickness.
Review in Deutsches Arzteblatt international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Prevalence and risk factors for nausea and vomiting in breast cancer patients undergoing chemotherapy.Acta oncologica (Stockholm, Sweden) · 2026Pooled it
- Investigation of Heart Rate Variability Indices in Motion Sickness.Sensors (Basel, Switzerland) · 2026Pooled it
- Evaluation of effects of optokinetic and rotational stimuli with functional head impulse test (fHIT) in individuals with motion sickness.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Trial
- Tradipitant: First Approval.Drugs · 2026Review
- Article
- Case Report: Relief of long-standing severe motion sickness following stellate ganglion block.Frontiers in neuroscience · 2026Article
- The gut feeling in motion sickness.Communications biology · 2025Review
- [Risk assessment of residual dizziness after repositioning in patients with benign paroxysmal positional vertigo according on multivariate analysis and nomogram].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Article
- Subjective visual vertical in first time seafarers experiencing sea sickness.Journal of otology · 2025Article
- Preparation and evaluation of immediate and modified release tablets contained diphenidol hydrochloride.Scientific reports · 2025Article
- Modulation of vestibular function and receptor expression by experimental hypergravity in a rat model.Scientific reports · 2025Article
- Functional and imaging anomalies of the vestibular system in motion sickness: a clinical observation study.BMC medical imaging · 2025Observational
- Episodic Migraine in the Pediatric Population: Behavioral Therapies and other Non-Pharmacological Treatment Options.Current pain and headache reports · 2025Review
- Autoimmune encephalitis with dizziness in children: A case report presented to the otolaryngology department.Medicine · 2025Article
- Motion Syros: tradipitant effective in the treatment of motion sickness; a multicenter, randomized, double-blind, placebo-controlled study.Frontiers in neurology · 2025Article
- Effects of two kinds of vestibular function training on reducing motion sickness in college students.Frontiers in neurology · 2025Article
- Preventive Effect of Hydroxyzine on Postoperative Nausea and Vomiting: A Single-Center, Retrospective, Observational Cohort Study.Journal of clinical medicine · 2024Article
- Relationship Between Motion Sickness Susceptibility and Vestibular Test Results.Medeniyet medical journal · 2024Article
- Development and Evaluation of a Virtual Reality Simulator for Spinal Cord Stimulation: A Randomized Controlled Trial.Journal of pain research · 2024Article
- Development of a new immersive virtual reality (VR) headset-based dexterity training for patients with multiple sclerosis: Clinical and technical aspects.Technology and health care : official journal of the European Society for Engineering and Medicine · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeasickness and travel sickness are classic types of motion illness. Modern simulation systems and virtual reality representations can also induce comparable symptoms. Such manifestations can be alleviated or prevented by various measures.
methodsThis review is based on pertinent publications retrieved by a PubMed search, with special attention to clinical trials and review articles.
resultsIndividuals vary in their susceptibility to autonomic symptoms, ranging from fatigue to massive vomiting, induced by passive movement at relatively low frequencies (0.2 to 0.4 Hz) in situations without any visual reference to the horizontal plane. Younger persons and women are considered more susceptible, and twin studies have revealed a genetic component as well. The various types of motion sickness are adequately explained by the intersensory conflict model, incorporating the vestibular, visual, and proprioceptive systems and extended to include consideration of postural instability and asymmetry of the otolith organs. Scopolamine and H1-antihistamines, such as dimenhydrinate and cinnarizine, can be used as pharmacotherapy. The symptoms can also be alleviated by habituation through long exposure or by the diminution of vestibular stimuli.
conclusionThe various types of motion sickness can be treated with general measures to lessen the intersensory conflict, behavioral changes, and drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.