Evidence map›Paper›PMID 30406513›Full record

ArticleMolecular imaging and biology2019

Spatial Concordance of Tumor Proliferation and Accelerated Repopulation from Pathologic Images to 3'-[

Chengming Li, Xiaoli Zhang, Linlin Pang, Yong Huang, Yongsheng Gao, Xindong Sun, Jinming Yu, Xue Meng

Abstract read
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In one paragraph

Article in Molecular imaging and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Transpathology: molecular imaging-based pathology.European journal of nuclear medicine and molecular imaging · 2021
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chengming LiSchool of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, China.
Xiaoli ZhangDepartment of Radiation Oncology, Shandong Academy of Medical Science, Shandong Cancer Hospital Affiliated to Shandong University, No 440, Jiyan Road, Jinan, 250117, China.
Linlin PangDepartment of Radiation Oncology, Shandong Academy of Medical Science, Shandong Cancer Hospital Affiliated to Shandong University, No 440, Jiyan Road, Jinan, 250117, China.
Yong HuangDepartment of Nuclear Medicine, Shandong Academy of Medical Science, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China.
Yongsheng GaoDepartment of Pathology, Shandong Academy of Medical Science, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China.
Xindong SunDepartment of Radiation Oncology, Shandong Academy of Medical Science, Shandong Cancer Hospital Affiliated to Shandong University, No 440, Jiyan Road, Jinan, 250117, China.
Jinming YuDepartment of Radiation Oncology, Shandong Academy of Medical Science, Shandong Cancer Hospital Affiliated to Shandong University, No 440, Jiyan Road, Jinan, 250117, China.
Xue MengDepartment of Radiation Oncology, Shandong Academy of Medical Science, Shandong Cancer Hospital Affiliated to Shandong University, No 440, Jiyan Road, Jinan, 250117, China. mengxue5409@126.com.ORCID 0000-0001-7925-7295

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess tumor cell proliferation and repopulation during fractionated radiotherapy and investigate the spatial concordance of cell proliferation and repopulation according to the uptake of 3'-[ PROCEDURES: Mice bearing A549 xenograft tumors were assigned to five irradiated groups, including 3 fraction (f)/6 days (d), 6f/12d, 9f/18d, 12f/24d, and 18f/36d with 2 Gy/f irradiations performed every other day and one non-irradiated group. Serial [

resultsThe SUVmax decreased in the 3f/6d group (P = 0.000) compared to the non-irradiated group, increased in the 6f/12d group and then gradually reduced with prolonged treatment. Proliferation changes in 6f/12d group on pathology images were also confirmed. Significant correlations were found between the SUVmax and Ki-67 LI in each in vitro tumor of cell proliferation group and accelerated repopulation group (both of the P < 0.001). Furthermore, the mean overlap region rates (ORRs) were 56.21 % and 57.82 % in the proliferation group and repopulation group, respectively. The data represented the preferable registration.

conclusions[

Indexed as

Positron-Emission TomographyRadiotherapy DosageA549 CellsAnimalsCell ProliferationDideoxynucleosidesFeasibility StudiesFemaleHumansLung NeoplasmsMice, Inbred BALB CMice, NudeTomography, X-Ray ComputedalovudineDideoxynucleosides[18F]FLT PET/CTNon-small cell lung cancerRadiotherapy dose paintingSpatial concordanceTumor accelerated repopulation

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.