ArticleEuropean radiology2019
Dual-energy CT for liver iron quantification in patients with haematological disorders.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 28 citations in OpenAlex.
- Experimental Characterisation of Differently Composed Thrombus Entities with Spectral-Detector-CT.Neurology international · 2026Article
- Photon-Counting Computed Tomography-Based Hepatic iron Quantification Using a Tungsten-Based Contrast Agent.Investigative radiology · 2025Article
- Iron chelation therapy in myelodysplastic syndromes and allogeneic hematopoietic cell transplantation, a delicate balance.Blood reviews · 2025Review
- Spectral performance evaluation of a second-generation spectral detector CT.Journal of applied clinical medical physics · 2024Article
- Imaging of metabolic and overload disorders in tissues and organs.Japanese journal of radiology · 2023Review
- Quantitative Analysis of Liver Iron Deposition Based on Dual-Energy CT in Thalassemia Patients.Mediterranean journal of hematology and infectious diseases · 2023Article
- Quantitative T2* MRI for bone marrow iron overload: normal reference values and assessment in thalassemia major patients.La Radiologia medica · 2022Article
- Quantitative dual-energy CT techniques in the abdomen.Abdominal radiology (New York) · 2022Review
- Computed Tomography Techniques, Protocols, Advancements, and Future Directions in Liver Diseases.Magnetic resonance imaging clinics of North America · 2021Review
- Diagnostic evaluation and ablation treatments assessment in hepatocellular carcinoma.Infectious agents and cancer · 2021Review
- Comparative Study on Iron Content Detection by Energy Spectral CT and MRI in MDS Patients.Frontiers in oncology · 2021Article
- Lower limit of iron quantification using dual-energy CT - a phantom study.Journal of applied clinical medical physics · 2021Article
- Dual-energy CT in diffuse liver disease: is there a role?Abdominal radiology (New York) · 2020Review
- Investigating Dual-Energy CT Post-Contrast Phases for Liver Iron Quantification: A Preliminary Study.Dose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo retrospectively quantify liver iron content in haematological patients suspected of transfusional haemosiderosis using dual-energy CT (DECT) and correlate with serum ferritin levels and estimated quantity of transfused iron.
methodsOne hundred forty-seven consecutive dual-source dual-energy non-contrast chest-CTs in 110 haematologic patients intended primarily for exclusion of pulmonary infection between September 2016 and June 2017 were retrospectively evaluated. Image data was post-processed with a software prototype. After material decomposition, an iron enhancement map was created and freehand ROIs were drawn including most of the partially examined liver. The virtual iron content (VIC) was calculated and expressed in milligram/millilitre. VIC was correlated with serum ferritin and estimated amount of transfused iron. Scans of patients who had not received blood products were considered controls.
resultsForty-eight (32.7%) cases (controls) had not received any blood transfusions whereas 67.3% had received one transfusion or more. Median serum ferritin and VIC were 138.0 μg/dl (range, 6.0-2628.0 μg/dl) and 1.33 mg/ml (range, - 0.94-7.56 mg/ml) in the post-transfusional group and 27.0 μg/dl (range, 1.0-248.0 μg/dl) and 0.61 mg/ml (range, - 2.1-2.4) in the control group. Correlation between serum ferritin and VIC was strong (r = 0.623; p < 0.001) as well as that between serum ferritin and estimated quantity of transfused iron (r = 0.681; p < 0.001).
conclusionsHepatic VIC obtained via dual-energy chest-CT examinational protocol strongly correlates with serum ferritin levels and estimated amount of transfused iron and could therefore be used in the routine diagnosis for complementary evaluation of transfusional haemosiderosis. KEY POINTS: • Virtual liver iron content was measured in routine chest-CTs of haematological patients suspected of having iron overload. Chest-CTs were primarily intended for exclusion of pulmonary infection. • Measurements correlate strongly with the most widely used blood marker of iron overload serum ferritin (after exclusion of infection) and the amount of transfused iron. • Liver VIC could be used for supplemental evaluation of transfusional haemosiderosis in haematological patients.
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