Evidence map›Paper›PMID 30406176›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2018

Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry.

R Scott Mackin, Philip S Insel, Diana Truran, Shannon Finley, Derek Flenniken, Rachel Nosheny, Aaron Ulbright, Monica Comacho, David Bickford, Brian Harel and 2 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Article
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  6. Review
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  11. cCOG Web-Based Cognitive Assessment Tool.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  12. Article
  13. Article
  14. Brain health registry updates: An online longitudinal neuroscience platform.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  15. Observational
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

R Scott MackinDepartment of Psychiatry, University of California, San Francisco, CA, USA.
Philip S InselCenter for Imaging of Neurodegenerative Diseases (CIND) San Francisco Veterans Affair Medical Center, San Francisco, CA, USA.
Diana TruranCenter for Imaging of Neurodegenerative Diseases (CIND) San Francisco Veterans Affair Medical Center, San Francisco, CA, USA.
Shannon FinleyCenter for Imaging of Neurodegenerative Diseases (CIND) San Francisco Veterans Affair Medical Center, San Francisco, CA, USA.
Derek FlennikenCenter for Imaging of Neurodegenerative Diseases (CIND) San Francisco Veterans Affair Medical Center, San Francisco, CA, USA.
Rachel NoshenyCenter for Imaging of Neurodegenerative Diseases (CIND) San Francisco Veterans Affair Medical Center, San Francisco, CA, USA.
Aaron UlbrightCenter for Imaging of Neurodegenerative Diseases (CIND) San Francisco Veterans Affair Medical Center, San Francisco, CA, USA.
Monica ComachoCenter for Imaging of Neurodegenerative Diseases (CIND) San Francisco Veterans Affair Medical Center, San Francisco, CA, USA.
David BickfordDepartment of Psychiatry, University of California, San Francisco, CA, USA.
Brian HarelPfizer, USA.
Paul MaruffCogstate Inc, USA.
Michael W WeinerDepartment of Psychiatry, University of California, San Francisco, CA, USA.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
Prediction of cognitive decline with structural, diffusion, and perfusion MRIR01AG010897 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI WEINER, MICHAEL W · 1992 to 2013
$9.4M
Characterizing Cognitive Decline in Late Life Depression: The ADNI-D ProjectR01MH098062 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Robert Scott Mackin · 2013 to 2026
$9.1M
Multimodal MRI Characteristics of Psychotherapy Response in Late Life DepressionR01MH101472 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MACKIN, ROBERT SCOTT, TOSUN-TURGUT, DUYGU · 2015 to 2019
$3.3M
Implementation and validation of an online Caregiver and Study Partner Portal for assessment of cognitive function in older adultsK01AG055692 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOSHENY, RACHEL LAUREN · 2017 to 2021
$719k
CSRD VA I01 CX000798NIA NIH HHS K01 AG055692NIA NIH HHS P01 AG019724NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG010897NIA NIH HHS U01 AG024904NIMH NIH HHS R01 MH098062NIMH NIH HHS R01 MH101472
6 · The paper itself

Abstract

introductionThe purpose of this study is to compare online neuropsychological test performance of older adults across self-reported diagnoses of being cognitively normal, mild cognitive impairment, and dementia due to Alzheimer's disease and to determine the association of memory concerns and family history of dementia on cognitive performance.

methodsParticipants completed the Cogstate Brief Battery unsupervised at home.

resultsData from 6463 participants over the age of 55 years were analyzed. Adults with the diagnosis of mild cognitive impairment and Alzheimer's disease were associated with poorer performance on all cognitive tests than cognitively normal adults ( DISCUSSION: Our results provide preliminary support for the use of cognitive tests taken online without supervision as a means to improve the efficiency of participant screening and recruitment for clinical trials.

Indexed as

AttentionBrain health registryDementiaInformation-processing speedInternetMemoryMild cognitive impairmentOnline cognitive testsResearch registry

Identifiers

PMID30406176
PMCPMC6215059

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.