ArticleBioMed research international2018
Risk Evaluation of Azithromycin-Induced QT Prolongation in Real-World Practice.
Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 5 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 5 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- The Spectrum of Antibiotic Prescribing During COVID-19 Pandemic: A Systematic Literature Review.Microbial drug resistance (Larchmont, N.Y.) · 2021Pooled it
- HRS/EHRA/APHRS/LAHRS/ACC/AHA Worldwide Practice Update for Telehealth and Arrhythmia Monitoring During and After a Pandemic.Journal of the American College of Cardiology · 2020Guideline
- HRS/EHRA/APHRS/LAHRS/ACC/AHA worldwide practice update for telehealth and arrhythmia monitoring during and after a pandemic.Heart rhythm · 2020Guideline
- Considerations for drug interactions on QTc interval in exploratory COVID-19 treatment.Heart rhythm · 2020Guideline
- Considerations for Drug Interactions on QTc Interval in Exploratory COVID-19 Treatment.Journal of the American College of Cardiology · 2020Guideline
- Review
- Factors associated with clinically diagnosed long QT syndrome in Korean adults: a nationwide case-control study.Frontiers in pharmacology · 2026Article
- Emerging Anti-Inflammatory COPD Treatments: Potential Cardiovascular Impacts.International journal of chronic obstructive pulmonary disease · 2024Review
- Evaluation of rosuvastatin-induced QT prolongation risk using real-world data, in vitro cardiomyocyte studies, and mortality assessment.Scientific reports · 2023Article
- Treating asthma in the time of COVID.The Journal of allergy and clinical immunology · 2023Article
- Effects of azithromycin on ventricular repolarization in children with COVID-19.Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology · 2022Article
- Article
- Predicting QT interval prolongation in patients diagnosed with the 2019 novel coronavirus infection.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2021Article
- Quality, efficacy, safety-it is not enough!European journal of clinical pharmacology · 2021Article
- The effect of the severity COVID-19 infection on electrocardiography.The American journal of emergency medicine · 2021Article
- What the dental practitioner needs to know about pharmaco-therapeutic modalities of COVID-19 treatment: A review.Journal of dental sciences · 2021Review
- Cardiac safety and potential efficacy: two reasons for considering minocycline in place of azithromycin in COVID-19 management.European heart journal. Cardiovascular pharmacotherapy · 2021Article
- Potential Drug Interactions of Repurposed COVID-19 Drugs with Lung Cancer Pharmacotherapies.Archives of medical research · 2021Review
- Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?Pharmacology & therapeutics · 2021Review
- COVID-19 and the burning issue of drug interaction: never forget the ECG.Postgraduate medical journal · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAzithromycin exposure has been reported to increase the risk of QT prolongation and cardiovascular death. However, findings on the association between azithromycin and cardiovascular death are controversial, and azithromycin is still used in actual practice. Additionally, quantitative assessments of risk have not been performed, including the risk of QT prolongation when patients are exposed to azithromycin in a real-world clinical setting. Therefore, in this study, we aimed to evaluate the risk of exposure to azithromycin on QT prolongation in a real-world clinical setting using a 21-year medical history database of a tertiary medical institution.
methodsWe analyzed the electrocardiogram results and relevant electronic health records of 402,607 subjects in a tertiary teaching hospital in Korea from 1996 to 2015. To evaluate the risk of QT prolongation of azithromycin, we conducted a case-control analysis using amoxicillin for comparison. Multiple logistic regression analysis was performed to correct for age, sex, accompanying drugs, and disease.
resultsThe odds ratio (OR) for QT prolongation (QTc>450 ms in male and >460 ms in female) on azithromycin exposure was 1.40 (95% confidence interval [CI], 1.23-1.59), and the OR for severe QT prolongation (QTc>500 ms) was 1.43 (95% CI, 1.13-1.82). On the other hand, the ORs on exposure to amoxicillin were 1.06 (95% CI, 0.97-1.15) and 0.88 (95% CI, 0.70-1.09). In a subgroup analysis, the risk of QT prolongation in patients aged between 60 and 80 years was significantly higher when they are exposed to azithromycin.
conclusionsThe risk of QT prolongation was increased when patients, particularly the elderly aged 60-79 years, were exposed to azithromycin. Therefore, clinicians should pay exercise caution using azithromycin or consider using other antibiotics, such as amoxicillin, instead of azithromycin.
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