Evidence map›Paper›PMID 30405872›Full record

ArticleJournal of biomedical science and engineering2017

Development of an Artificial Finger-Like Knee Loading Device to Promote Bone Health.

Sandeep Korupolu, Stanley Chien, Hiroki Yokota, Sohel Anwar

Abstract read
In one paragraph

Article in Journal of biomedical science and engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sandeep KorupoluDepartment of Mechanical Engineering, Indiana University Purdue University Indianapolis (IUPUI), Indianapolis, IN, USA.
Stanley ChienDepartment of Electrical and Computer Engineering, Indiana University Purdue University Indianapolis (IUPUI), Indianapolis, IN, USA.
Hiroki YokotaDepartment of Biomedical Engineering, Indiana University Purdue University Indianapolis (IUPUI), Indianapolis, IN, USA.
Sohel AnwarDepartment of Mechanical Engineering, Indiana University Purdue University Indianapolis (IUPUI), Indianapolis, IN, USA.

Funding

MECHANICAL LOADING AND BONER01AR052144 · NIAMS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI YOKOTA, HIROKI · 2006 to 2018
$4.2M
NIAMS NIH HHS R01 AR052144
6 · The paper itself

Abstract

This study presents the development of an innovative artificial finger-like device that provides position specific mechanical loads at the end of the long bone and induces mechanotransduction in bone. Bone cells such as osteoblasts are the mechanosensitive cells that regulate bone remodelling. When they receive gentle, periodic mechanical loads, new bone formation is promoted. The proposed device is an under-actuated multi-fingered artificial hand with 4 fingers, each having two phalanges. These fingers are connected by mechanical linkages and operated by a worm gearing mechanism. With the help of 3D printing technology, a prototype device was built mostly using plastic materials. The experimental validation results show that the device is capable of generating necessary forces at the desired frequencies, which are suitable for the stimulation of bone cells and the promotion of bone formation. It is recommended that the device be tested in a clinical study for confirming its safety and efficacy with patients.

Indexed as

Artificial HandBone GrowthMechanical LoadingOsteoblasts

Identifiers

PMID30405872
PMCPMC6217823

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.