Evidence map›Paper›PMID 30405861›Full record

ArticlePain research & management2018

Preconditioning Contractions Suppress Muscle Pain Markers after Damaging Eccentric Contractions.

Hiroshi Nagahisa, Kazumi Ikezaki, Ryotaro Yamada, Takashi Yamada, Hirofumi Miyata

Abstract read
In one paragraph

Article in Pain research & management, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Eccentric Exercise and Muscle Damage: An Introductory Guide.Journal of functional morphology and kinesiology · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hiroshi NagahisaBiological Sciences, Graduate School of Sciences and Technology for Innovation, Yamaguchi University, Yoshida 1677-1, Yamaguchi 753-8515, Japan.
Kazumi IkezakiBiological Sciences, Graduate School of Sciences and Technology for Innovation, Yamaguchi University, Yoshida 1677-1, Yamaguchi 753-8515, Japan.
Ryotaro YamadaGraduate School of Health Sciences, Sapporo Medical University, Sapporo 060-8556, Japan.
Takashi YamadaGraduate School of Health Sciences, Sapporo Medical University, Sapporo 060-8556, Japan.
Hirofumi MiyataBiological Sciences, Graduate School of Sciences and Technology for Innovation, Yamaguchi University, Yoshida 1677-1, Yamaguchi 753-8515, Japan.ORCID 0000-0001-6462-4726

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inexperienced vigorous exercise, including eccentric contraction (ECC), causes muscle pain and damage. Similar prior light exercise suppresses the development of muscle pain (repeated-bout effect), but the molecular mechanisms behind this are not sufficiently understood. In this study, the influence of a nondamaging preconditioning ECC load (Precon) on muscle pain-related molecules and satellite cell-activating factors was investigated at the mRNA expression level. Nine-week-old male Wistar rats (

Indexed as

AnimalsCyclooxygenase 2Disease Models, AnimalGene Expression RegulationHepatocyte Growth FactorHistocompatibility Antigens Class IMaleMuscle ContractionMuscle, SkeletalMyalgiaMyoD ProteinPaired Box Transcription FactorsPhysical Conditioning, AnimalProstaglandin-E SynthasesRatsRats, WistarCyclooxygenase 2Hepatocyte Growth FactorHistocompatibility Antigens Class IMyoD ProteinPaired Box Transcription FactorsPAX7 protein, ratProstaglandin-E SynthasesPtgs2 protein, ratReceptor, Bradykinin B2RNA, Messenger

Identifiers

PMID30405861
PMCPMC6204166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.