ArticleDisease markers2018
Amino Acid-Based Metabolic Panel Provides Robust Prognostic Value Additive to B-Natriuretic Peptide and Traditional Risk Factors in Heart Failure.
Article in Disease markers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Metabolomic profiling of infants undergoing cardiopulmonary bypass and association with clinical outcomes: a systematic review.Frontiers in cardiovascular medicine · 2024Pooled it
- Perioperative Metabolites Are Associated With Adverse Neonatal Congenital Heart Disease Surgical Outcomes.Journal of the American Heart Association · 2022Trial
- Analysis of serum NMR metabolomics in fibrotic diseases of the myocardium.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- The Use of Metabolomes in Risk Stratification of Patients with Heart Failure: A Scoping Review.Life (Basel, Switzerland) · 2026Review
- Blueprint of the distinct metabolite profiles of healthy pig heart chambers.Journal of molecular and cellular cardiology plus · 2025Article
- Metabolomic Panel for the Diagnosis of Heart Failure with Preserved Ejection Fraction.International journal of molecular sciences · 2025Article
- Using Omics to Identify Novel Therapeutic Targets in Heart Failure.Circulation. Genomic and precision medicine · 2024Review
- Causal association between blood metabolites and risk of hypertension: a Mendelian randomization study.Frontiers in cardiovascular medicine · 2024Article
- Energy intake insufficiency due to underestimated energy requirement by common predictive formulas can be identified by urinary amino acid levels in advanced heart failure.Frontiers in nutrition · 2024Article
- Discrimination of serum metabolomics profiles in infants with sepsis, based on liquid chromatography-mass spectrometer.BMC infectious diseases · 2023Article
- Article
- Understanding How Heart Metabolic Derangement Shows Differential Stage Specificity for Heart Failure with Preserved and Reduced Ejection Fraction.Biomolecules · 2022Review
- Article
- The treatment of Qibai Pingfei Capsule on chronic obstructive pulmonary disease may be mediated by Th17/Treg balance and gut-lung axis microbiota.Journal of translational medicine · 2022Article
- Amino Acid and Phospholipid Metabolism as an Indicator of Inflammation and Subtle Cardiomyopathy in Patients with Marfan Syndrome.Metabolites · 2021Article
- Prognostic value of leucine/phenylalanine ratio as an amino acid profile of heart failure.Heart and vessels · 2021Observational
- Interplay Between Gut Microbiota and Amino Acid Metabolism in Heart Failure.Frontiers in cardiovascular medicine · 2021Review
- Effects of myocardial ischemia/reperfusion injury on plasma metabolomic profile during aging.Aging cell · 2021Article
- Method comparison of HPLC-ninhydrin-photometry and UHPLC-PITC-tandem mass spectrometry for serum amino acid analyses in patients with complex congenital heart disease and controls.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Elevated plasma phenylalanine predicts mortality in critical patients with heart failure.ESC heart failure · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic disturbances represent functional perturbation in peripheral tissues and predict outcomes in patients with heart failure (HF). This study developed an amino acid-based metabolic panel and sought to see whether this panel could add diagnostic and prognostic value to currently used B-type natriuretic peptide (BNP) measurements. Mass spectrometry and ultra-performance liquid chromatography were performed on 1288 participants, including 129 normal controls and 712 patients at HF stages A to D in the initial cohort and 447 stage C patients in the validation cohort. Patients were followed up for composite events (death/HF-related rehospitalization). Histidine, ornithine, and phenylalanine were 3 metabolites found strongly significant to identify patients at stage C and were adopted to develop the HOP panel. Compared to BNP, HOP had better value in discriminating the patients at different stages, especially in elderly patients and those with atrial fibrillation, high body mass index, or kidney dysfunction. HOP was correlated with the distance of 6 min walking distance better than BNP. For prognosis, HOP predicted composite events in patients at stages C and D, independent of log (BNP), age, sex, left ventricular ejection fraction, New York Heart Association functional class, HF stage, diabetes mellitus, chronic kidney disease, hypertension, hemoglobin, and albumin. Higher BNP (≥750 pg/mL) along with higher HOP (≥14) robustly predicted lower event-free survival compared to all others [hazard ratio = 3.15 (2.23-4.46),
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