Evidence map›Paper›PMID 30405799›Full record

ArticleOncology letters2018

Ethnicity based variation in expression of E-cadherin in patients with squamous cell carcinoma of the oral tongue.

Nicola Sgaramella, Torben Wilms, Linda Boldrup, Lotta Loljung, Xiaolian Gu, Philip J Coates, Petra Hassellöf, Luigi Califano, Lorenzo Lo Muzio, Robin Fåhraeus and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Nicola SgaramellaDepartment of Medical Biosciences, Umeå University, SE-901 85 Umeå, Sweden.
Torben WilmsDepartment of Clinical Sciences/ENT, Umeå University, SE-901 85 Umeå, Sweden.
Linda BoldrupDepartment of Medical Biosciences, Umeå University, SE-901 85 Umeå, Sweden.
Lotta LoljungDepartment of Medical Biosciences, Umeå University, SE-901 85 Umeå, Sweden.
Xiaolian GuDepartment of Medical Biosciences, Umeå University, SE-901 85 Umeå, Sweden.
Philip J CoatesRECAMO, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
Petra HassellöfDepartment of Medical Biosciences, Umeå University, SE-901 85 Umeå, Sweden.
Luigi CalifanoDepartment of Neuroscience Reproductive and Dentistry Sciences, University of Naples Federico II, I-801 38 Naples, Italy.
Lorenzo Lo MuzioDepartment of Clinical and Experimental Medicine, University of Foggia, I-71122 Foggia, Italy.
Robin FåhraeusDepartment of Medical Biosciences, Umeå University, SE-901 85 Umeå, Sweden.
Lena Norberg SpaakDepartment of Clinical Sciences/ENT, Umeå University, SE-901 85 Umeå, Sweden.
Renato FrancoDipartimento Universitario di Anatomia Patologica, Second University of Naples, Piazza Miraglia, I-801 38 Naples, Italy.
Gianpaolo TartaroMultidisciplinary Department of Medical, Surgical and Dental Specialties, Second University of Naples, I-801 38 Naples, Italy.
Giuseppe ColellaMultidisciplinary Department of Medical, Surgical and Dental Specialties, Second University of Naples, I-801 38 Naples, Italy.
Mario SantagataMultidisciplinary Department of Medical, Surgical and Dental Specialties, Second University of Naples, I-801 38 Naples, Italy.
Giovanni Dell'Aversana OrabonaDepartment of Neuroscience Reproductive and Dentistry Sciences, University of Naples Federico II, I-801 38 Naples, Italy.
Fabrizio ChiricoMultidisciplinary Department of Medical, Surgical and Dental Specialties, Second University of Naples, I-801 38 Naples, Italy.
Karin DanielssonDepartment of Odontology, Umeå University, SE-901 85 Umeå, Sweden.
Giuseppe TroianoDepartment of Clinical and Experimental Medicine, University of Foggia, I-71122 Foggia, Italy.
Fatima ArditoDepartment of Clinical and Experimental Medicine, University of Foggia, I-71122 Foggia, Italy.
Karin NylanderDepartment of Medical Biosciences, Umeå University, SE-901 85 Umeå, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The oral tongue is the most common site for tumours within the oral cavity. Despite intense research, there has been no improvement in the survival rate for patients with oral tongue squamous cell carcinoma (OTSCC) during the last decades. Differences between oral cancer patients based on ethno-geographical distribution have been reported. The present study used immunohistochemistry to evaluate commonly used markers of cancer cell phenotypes, E-cadherin, β-catenin and cytokeratins 5 and 19, in 120 patients with OTSCC. To evaluate the impact of ethnicity, patients from Sweden and Italy were included. A higher proportion of Swedish patients exhibited high expression of E-cadherin in their tumours (P=0.039), and high levels of E-cadherin in Swedish OTSCC patients that had succumbed to their disease were associated with poor prognosis. These data demonstrated differences in the pathological characteristics of OTSCC between two different European populations. The findings emphasise the need to take ethnicity/geographical location of patients into account when comparing results from different studies of OTSCC.

Indexed as

beta cateninE-cadherinethnicityoral tonguesquamous cell carcinoma

Identifiers

PMID30405799
PMCPMC6202509

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.