Evidence map›Paper›PMID 30405702›Full record

ArticleFrontiers in genetics2018

SNPs Associated With Testosterone Levels Influence Human Facial Morphology.

Jasmien Roosenboom, Karlijne Indencleef, Myoung Keun Lee, Hanne Hoskens, Julie D White, Dongjing Liu, Jacqueline T Hecht, George L Wehby, Lina M Moreno, Carolyn Hodges-Simeon and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 3 countries.

Jasmien RoosenboomDepartment of Oral Biology, Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA, United States.
Karlijne IndencleefESAT-PSI, Department of Electrical Engineering, Medical Imaging Research Center, KU Leuven, Leuven, Belgium.
Myoung Keun LeeDepartment of Oral Biology, Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA, United States.
Hanne HoskensESAT-PSI, Department of Electrical Engineering, Medical Imaging Research Center, KU Leuven, Leuven, Belgium.
Julie D WhiteDepartment of Anthropology, Penn State University, University Park, PA, United States.
Dongjing LiuDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, United States.
Jacqueline T HechtDepartment of Pediatrics, University of Texas McGovern Medical Center, Houston, TX, United States.
George L WehbyDepartment of Health Management and Policy, University of Iowa, Iowa City, IA, United States.
Lina M MorenoDepartment of Orthodontics, University of Iowa, Iowa City, IA, United States.
Carolyn Hodges-SimeonDepartment of Anthropology, Boston University, Boston, MA, United States.
Eleanor FeingoldDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, United States.
Mary L MarazitaDepartment of Oral Biology, Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA, United States.
Stephen RichmondApplied Clinical Research and Public Health, School of Dentistry, Cardiff University, College of Biomedical and Life Sciences, Cardiff, United Kingdom.
Mark D ShriverDepartment of Anthropology, Penn State University, University Park, PA, United States.
Peter ClaesESAT-PSI, Department of Electrical Engineering, Medical Imaging Research Center, KU Leuven, Leuven, Belgium.
John R ShafferDepartment of Oral Biology, Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA, United States.
Seth M WeinbergDepartment of Oral Biology, Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA, United States.
University of Pittsburgh · USKU Leuven · BEPennsylvania State University · USUniversity of Iowa · USBoston University · USCardiff University · GBThe University of Texas Health Science Center at Houston · US

Funding

Extending the Phenotype of Nonsyndromic Orofacial CleftsR01DE016148 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L., WEINBERG, SETH M · 2004 to 2018
$19.7M
The Genetic Architecture of Human Facial MorphologyR01DE027023 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CLAES, PETER, SHAFFER, JOHN R · 2017 to 2024
$5.2M
3D Analysis of Normal Facial Variation: Data Repository and Genetics (Research)U01DE020078 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L., WEINBERG, SETH M · 2009 to 2013
$2.0M
Medical Research Council G9815508NHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008INIDCR NIH HHS R01 DE016148NIDCR NIH HHS R01 DE027023NIDCR NIH HHS U01 DE020078Wellcome Trust
6 · The paper itself

Abstract

Many factors influence human facial morphology, including genetics, age, nutrition, biomechanical forces, and endocrine factors. Moreover, facial features clearly differ between males and females, and these differences are driven primarily by the influence of sex hormones during growth and development. Specific genetic variants are known to influence circulating sex hormone levels in humans, which we hypothesize, in turn, affect facial features. In this study, we investigated the effects of testosterone-related genetic variants on facial morphology. We tested 32 genetic variants across 22 candidate genes related to levels of testosterone, sex hormone-binding globulin (SHGB) and dehydroepiandrosterone sulfate (DHEAS) in three cohorts of healthy individuals for which 3D facial surface images were available (Pittsburgh 3DFN, Penn State and ALSPAC cohorts; total

Indexed as

ALSPACcandidate SNPfacial morphologyfacial ratioSHBGtestosterone

Identifiers

PMID30405702
PMCPMC6206510
OpenAlexW2897907631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.