Evidence map›Paper›PMID 30405638›Full record

ArticleFrontiers in immunology2018

LIGHT/TNFSF14 as a New Biomarker of Bone Disease in Multiple Myeloma Patients Experiencing Therapeutic Regimens.

Giacomina Brunetti, Rita Rizzi, Giuseppina Storlino, Sara Bortolotti, Graziana Colaianni, Lorenzo Sanesi, Luciana Lippo, Maria Felicia Faienza, Anna Mestice, Paola Curci and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Biochemical bone biomarkers in plasma cell dyscrasias.British journal of haematology · 2026
    Review
  2. High levels of LIGHT/TNFSF14 in patients with Prader-Willi syndrome.Journal of endocrinological investigation · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Giacomina BrunettiSection of Human Anatomy and Histology, Department of Basic Medical Sciences, Neuroscience and Sense Organs, School of Medicine, University of Bari, Bari, Italy.
Rita RizziSection of Hematology, Department of Emergency and Organ Transplantation, School of Medicine, University of Bari, Bari, Italy.
Giuseppina StorlinoSection of Human Anatomy and Histology, Department of Emergency and Organ Transplantation, School of Medicine, University of Bari, Bari, Italy.
Sara BortolottiSection of Human Anatomy and Histology, Department of Emergency and Organ Transplantation, School of Medicine, University of Bari, Bari, Italy.
Graziana ColaianniSection of Human Anatomy and Histology, Department of Emergency and Organ Transplantation, School of Medicine, University of Bari, Bari, Italy.
Lorenzo SanesiSection of Human Anatomy and Histology, Department of Emergency and Organ Transplantation, School of Medicine, University of Bari, Bari, Italy.
Luciana LippoSection of Human Anatomy and Histology, Department of Emergency and Organ Transplantation, School of Medicine, University of Bari, Bari, Italy.
Maria Felicia FaienzaPaediatric Unit, Department of Biomedical Science and Human Oncology, University of Bari, Bari, Italy.
Anna MesticeSection of Hematology, Department of Emergency and Organ Transplantation, School of Medicine, University of Bari, Bari, Italy.
Paola CurciSection of Hematology, Department of Emergency and Organ Transplantation, School of Medicine, University of Bari, Bari, Italy.
Giorgina SpecchiaSection of Hematology, Department of Emergency and Organ Transplantation, School of Medicine, University of Bari, Bari, Italy.
Maria GranoSection of Human Anatomy and Histology, Department of Emergency and Organ Transplantation, School of Medicine, University of Bari, Bari, Italy.
Silvia ColucciSection of Human Anatomy and Histology, Department of Basic Medical Sciences, Neuroscience and Sense Organs, School of Medicine, University of Bari, Bari, Italy.
University of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously shown that through the production of high LIGHT levels, immune cells contribute to both osteoclastogenesis and bone destruction in Multiple Myeloma (MM)-related bone disease. With the aim of further exploring the mechanisms underlying the development of MM-related bone disease, here we focused on a possible role of LIGHT in MM patients with active bone disease despite the treatment received. We detected LIGHT over-expression by circulating CD14

Indexed as

AdultAgedAged, 80 and overAntibodies, BlockingAntineoplastic Combined Chemotherapy ProtocolsBiomarkersBone ResorptionCells, CulturedFemaleHumansLipopolysaccharide ReceptorsMaleMiddle AgedMonocytesMultiple MyelomaRANK LigandAntibodies, BlockingBiomarkersLipopolysaccharide ReceptorsRANK LigandTNFSF14 protein, humanTumor Necrosis Factor Ligand Superfamily Member 14bone diseaseCD14+/CD16+ monocytesLIGHT/TNFSF14multiple myelomaRANKL

Identifiers

PMID30405638
PMCPMC6206078
OpenAlexW2896189180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.