ArticleFrontiers in immunology2018
An RORγt Oral Inhibitor Modulates IL-17 Responses in Peripheral Blood and Intestinal Mucosa of Crohn's Disease Patients.
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Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Therapeutic Advancements in Psoriasis and Psoriatic Arthritis.Journal of clinical medicine · 2025Review
- Research Progress on Th17/Treg Cell Imbalance in Epileptic Seizures.Journal of inflammation research · 2025Review
- Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation.Cell & bioscience · 2023Article
- Small molecule inhibitors of RORγt for Th17 regulation in inflammatory and autoimmune diseases.Journal of pharmaceutical analysis · 2023Review
- The role of group 3 innate lymphoid cell in intestinal disease.Frontiers in immunology · 2023Review
- Targeting Lineage-Specific Transcription Factors and Cytokines of the Th17/Treg Axis by Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-International journal of molecular sciences · 2022Article
- Tackling Inflammatory Bowel Diseases: Targeting Proinflammatory Cytokines and Lymphocyte Homing.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Bile acids as inflammatory mediators and modulators of intestinal permeability.Frontiers in immunology · 2022Review
- Regulation of gut microbiota-bile acids axis by probiotics in inflammatory bowel disease.Frontiers in immunology · 2022Review
- Joint together: The etiology and pathogenesis of ankylosing spondylitis.Frontiers in immunology · 2022Review
- Interleukin-17-A multifaceted cytokine in viral infections.Journal of cellular physiology · 2021Review
- Review
- Bile Acid Signaling in Inflammatory Bowel Diseases.Digestive diseases and sciences · 2021Review
- Discovery of a Series of Pyrazinone RORγ Antagonists and Identification of the Clinical Candidate BI 730357.ACS medicinal chemistry letters · 2021Article
- Paradoxical Augmentation of Experimental Spondyloarthritis by RORC Inhibition in HLA-B27 Transgenic Rats.Frontiers in immunology · 2021Article
- Aucuboside Inhibits the Generation of Th17 Cells in Mice Colitis.Frontiers in pharmacology · 2021Article
- Gut microbiota from coronary artery disease patients contributes to vascular dysfunction in mice by regulating bile acid metabolism and immune activation.Journal of translational medicine · 2020Article
- Identification of key pathways and genes shared between Crohn's disease and breast cancer using bioinformatics analysis.Oncology letters · 2020Article
- VPR-254: an inhibitor of ROR-gamma T with potential utility for the treatment of inflammatory bowel disease.Inflammopharmacology · 2020Article
- (Inverse) Agonists of Retinoic Acid-Related Orphan Receptor γ: Regulation of Immune Responses, Inflammation, and Autoimmune Disease.Annual review of pharmacology and toxicology · 2020Review
Corrections and comments
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Authors and funding
23 authors at 5 institutions in 2 countries.
Helena Bassolas-MolinaDepartment of Gastroenterology, IDIBAPS, Hospital Clínic, CIBERehd, Barcelona, Spain.
Ernest RaymondDepartment of Immunology and Respiratory, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, United States.
Mark LabadiaDepartment of Immunology and Respiratory, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, United States.
Joseph WahleDepartment of Immunology and Respiratory, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, United States.
Elena Ferrer-PicónDepartment of Gastroenterology, IDIBAPS, Hospital Clínic, CIBERehd, Barcelona, Spain.
Mark PanzenbeckDepartment of Immunology and Respiratory, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, United States.
Jie ZhengDepartment of Immunology and Respiratory, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, United States.
Christian HarckenDepartment of Immunology and Respiratory, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, United States.
Robert HughesDepartment of Small Molecule Discovery Research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, United States.
Michael TurnerDepartment of Small Molecule Discovery Research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, United States.
Dustin SmithDepartment of Small Molecule Discovery Research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, United States.
Elisabeth Calderón-GómezDepartment of Gastroenterology, IDIBAPS, Hospital Clínic, CIBERehd, Barcelona, Spain.
Míriam EstellerDepartment of Gastroenterology, IDIBAPS, Hospital Clínic, CIBERehd, Barcelona, Spain.
Anna CarrascoDepartment of Gastroenterology, Hospital Universitari Mutua Terrassa, Barcelona, Spain.
Maria EsteveDepartment of Gastroenterology, Hospital Universitari Mutua Terrassa, Barcelona, Spain.
Isabella DottiDepartment of Gastroenterology, IDIBAPS, Hospital Clínic, CIBERehd, Barcelona, Spain.
Ana Maria CorralizaDepartment of Gastroenterology, IDIBAPS, Hospital Clínic, CIBERehd, Barcelona, Spain.
Maria Carme MasamuntDepartment of Gastroenterology, IDIBAPS, Hospital Clínic, CIBERehd, Barcelona, Spain.
Clàudia ArajolDepartment of Gastroenterology, Hospital Universitari de Bellvitge-IDIBELL, Barcelona, Spain.
Jordi GuardiolaDepartment of Gastroenterology, Hospital Universitari de Bellvitge-IDIBELL, Barcelona, Spain.
Elena RicartDepartment of Gastroenterology, IDIBAPS, Hospital Clínic, CIBERehd, Barcelona, Spain.
Gerald NaboznyDepartment of Immunology and Respiratory, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, United States.
Azucena SalasDepartment of Gastroenterology, IDIBAPS, Hospital Clínic, CIBERehd, Barcelona, Spain.
Boehringer Ingelheim (United States) · USCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESHospital Clínic de Barcelona · ESInstitut d'Investigació Biomédica de Bellvitge · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ES
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsAntigensBiomarkersBiopsyCrohn DiseaseCytokinesDisease Models, AnimalHumansInflammation MediatorsInterleukin-17Intestinal MucosaLeukocytes, MononuclearMiceNuclear Receptor Subfamily 1, Group F, Member 3Th17 CellsT-Lymphocyte SubsetsAntigensBiomarkersCytokinesInflammation MediatorsInterleukin-17Nuclear Receptor Subfamily 1, Group F, Member 3commensal antigensCrohn's diseaseRORγt inhibitionT-cell-transferTh17
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.