ArticleFrontiers in aging neuroscience2018
The Barcelona Brain Health Initiative: A Cohort Study to Define and Promote Determinants of Brain Health.
Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Technologies for Monitoring Lifestyle Habits Related to Brain Health: A Systematic Review.Sensors (Basel, Switzerland) · 2019Pooled it
- Sex differences in the associations between lifestyle, intestinal permeability and brain health in middle-aged adults.Brain, behavior, & immunity - health · 2026Article
- Middle-Aged and Older Adults' Beliefs, Ratings, and Preferences for Receiving Multicomponent Lifestyle-Based Brain Health Interventions.Brain sciences · 2026Article
- Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers.Brain communications · 2026Article
- Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change.Nature communications · 2025Article
- Mental Health and Aging: Identifying Risk and Protective Factors of Anxiety and Depression in Older Women.Aging medicine (Milton (N.S.W)) · 2025Article
- Reevaluating the role of education on cognitive decline and brain aging in longitudinal cohorts across 33 Western countries.Nature medicine · 2025Article
- Use of Multiple Languages Provides Cognitive Reserve Amidst Age-Related White Matter Changes.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Reevaluating the Role of Education in Cognitive Decline and Brain Aging: Insights from Large-Scale Longitudinal Cohorts across 33 Countries.Research square · 2025Article
- Reevaluating the Role of Education in Cognitive Decline and Brain Aging: Insights from Large-Scale Longitudinal Cohorts across 33 Countries.medRxiv : the preprint server for health sciences · 2025Article
- The Healthy Aging Initiative (HAI): an interdisciplinary longitudinal cohort study to characterize and promote healthspan in senior housing.Frontiers in public health · 2025Article
- Clustering on longitudinal lifestyle trajectories and their impact on cognitive performance.Frontiers in psychology · 2025Article
- Article
- A Mindfulness-Based Lifestyle Intervention for Dementia Risk Reduction: Protocol for the My Healthy Brain Feasibility Randomized Controlled Trial.JMIR research protocols · 2024Article
- Neurocognitive Effects of an Online Brain Health Program and Weekly Telehealth Support Group in Older Adults with Subjective Memory Loss: A Pilot Study.Geriatrics (Basel, Switzerland) · 2024Article
- Brain Health and Cognition in Older Adults: Roadmap and Milestones towards the Implementation of Preventive Strategies.Brain sciences · 2024Review
- A measure of modifiable lifestyle factors shaping subjective cognitive reserve in the general population.Frontiers in psychology · 2024Article
- Impact of repetitive negative thinking on subjective cognitive decline: insights into cognition and brain structure.Frontiers in aging neuroscience · 2024Article
- Lifestyle trajectories in middle-aged adults and their relationship with health indicators.Frontiers in public health · 2024Article
- Brain health assessment. An exploratory review of tools related to its cognitive dimension.Cerebral circulation - cognition and behavior · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Barcelona Brain Health Initiative (BBHI) is an ongoing prospective longitudinal study focused on identifying determinants of brain health. The main objectives are: (i) to characterize lifestyle, cognitive, behavioral and environmental markers related to a given individual's cognitive and mental functions in middle to old age, (ii) to assess the biological determinants predictive of maintenance of brain health, and (iii) to evaluate the impact of a controlled multi-dimensional lifestyle intervention on improving and maintaining brain health. The BBHI cohort consists of >4500 healthy participants aged 40-65 years followed through online questionnaires (Phase I) assessing participants' self-perceived health and lifestyle factors in seven different domains: overall health, physical exercise, cognitive activity, sleep, nutrition, social interactions, and life purpose. In Phase II a sub-group of 1,000 individuals is undergoing detailed in-person evaluations repeated at two-yearly intervals. These evaluations will provide deep phenotyping of brain function, including medical, neurological and psychiatric examinations, assessment of physical fitness, neuropsychological assessments, structural and functional brain magnetic resonance imaging, electroencephalography and perturbation-based non-invasive brain stimulation evaluations of brain activity, as well as collection of biological samples. Finally, in Phase III a further sub-group of 500 participants will undergo a similar in-person assessment before and after a multi-dimensional intervention to optimize lifestyle habits and evaluate its effects on cognitive and brain structure and function. The intervention group will receive remote supervision through an ICT-based solution, with the support of an expert in health and lifestyle coaching strategies aimed at promoting adherence. On the other hand, the control group will not have this coaching support, and will only receive education and recommendations about healthy habits. Results of this three-part initiative shall critically contribute to a better understanding of the determinants to promote and maintain brain health over the lifespan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.