ArticleFrontiers in behavioral neuroscience2018
Linalool Odor-Induced Anxiolytic Effects in Mice.
Article in Frontiers in behavioral neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Lavender aromatherapy: A systematic review from essential oil quality and administration methods to cognitive enhancing effects.Applied psychology. Health and well-being · 2022Pooled it
- Smelling Wellness: Associations Between Botanic Garden Scentscapes and Human Health Gains.International journal of environmental research and public health · 2026Trial
- Lavender-Neroli Aromatherapy for Reducing Dental Anxiety and Pain in Children During Anesthesia: A Two-Arm Randomized Controlled Trial.Medical sciences (Basel, Switzerland) · 2025Trial
- Review
- Considering Culinary Use of Lavender: Sensory and Cultural Factors.Foods (Basel, Switzerland) · 2026Review
- Article
- Terpenes as Potential Multi-Target Modulators of Chronic Stress-Induced Neuroendocrine-Immune Dysregulation.International journal of molecular sciences · 2026Review
- An Olfactory Piriform Cortex-Lateral Hypothalamus Neural Circuit Contributes to Linalool-Induced Analgesia.CNS neuroscience & therapeutics · 2026Article
- Integrated Chemical, In Silico, and Functional Neurobehavioral Evaluation of Three Essential Oils in Acute Anxiety- and Depression-Related Mouse Models.Molecules (Basel, Switzerland) · 2026Article
- Exploring Linalool-Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition.Phytotherapy research : PTR · 2026Review
- Pharmacological and molecular insights into linalool-richVeterinary world · 2025Article
- Caffeine and sclareol take the edge off the sedative effects of linalool, possibly through the GABAA interaction pathway: molecular insights through in vivo and in silico studies.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Using an aromatherapy intervention withInternational journal of nursing sciences · 2025Article
- An observational feasibility study on the impact of green exposure on major depressive episode symptomatology and inflammatory biomarkers.Frontiers in psychiatry · 2025Article
- The effects of Arabian jasmine on zebrafish behavior depends on strain, sex, and personality.PloS one · 2025Article
- Sex Differences in the Anxiolytic Properties of Common Cannabis Terpenes, Linalool and β-Myrcene, in Mice.NeuroSci · 2024Article
- Neuroprotective Properties of Coriander-Derived Compounds on Neuronal Cell Damage under Oxidative Stress-Induced SH-SY5Y Neuroblastoma and in Silico ADMET Analysis.Neurochemical research · 2024Article
- Comparing Effects of Aromatherapy with Five Herbs Essential Oils on PCPA-induced Insomnia Mice.Journal of microbiology and biotechnology · 2024Article
- Article
- Possible Combinatorial Utilization of Phytochemicals and Extracellular Vesicles for Wound Healing and Regeneration.International journal of molecular sciences · 2024Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In folk medicine, it has long been believed that odorous compounds derived from plant extracts can have anxiolytic effects. Among them, linalool, one of the terpene alcohols in lavender extracts, has been reported to have the anxiolytic effects. However, the anxiolytic nature of the linalool odor itself as well as its potential action through the olfactory system has not been thoroughly examined. In this study, we examined the anxiolytic effects of linalool odor with light/dark box test and with elevated plus maze (EPM), and found that linalool odor has an anxiolytic effect without motor impairment in mice. The effect was not observed in anosmic mice, indicating that it was triggered by olfactory input evoked by linalool odor. Furthermore, the effect was antagonized by flumazenil, indicating that the linalool odor-induced anxiolytic effect was mediated by γ-aminobutyric acid (GABA)ergic transmission via benzodiazepine (BDZ)-responsive GABA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.