ArticleFrontiers in neuroscience2018
Gray Matter Atrophy Is Associated With Cognitive Impairment in Patients With Presbycusis: A Comprehensive Morphometric Study.
Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- The impact of age-related hearing loss on structural neuroanatomy: A meta-analysis.Frontiers in neurology · 2022Pooled it
- Hearing Rehabilitative Treatment for Older Adults With Comorbid Hearing Loss and Depression: Effects on Depressive Symptoms and Executive Function.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Trial
- Gray matter declines with age and hearing loss, but is partially maintained in tinnitus.Scientific reports · 2020Trial
- Neurovascular-metabolic coupling links hearing loss to cognitive impairment: Evidence from GABA and cerebral blood flow in presbycusis.Neurobiology of disease · 2026Article
- Exploring the Relationship Between Hearing Loss and Cognitive Dysfunction from the Perspective of Molecular Mechanisms.Biomolecules · 2026Review
- Functional-Structural Coupling: Brain Reorganization in Presbycusis Is Related to Cognitive Impairment.eNeuro · 2026Article
- [Current status and future perspectives on age-related hearing loss and cognitive impairment].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Review
- [Research progress on the mechanism of auditory center remodeling and clinical intervention strategies in presbycusis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Review
- Short-term hearing aid use reduces auditory cortical responses to speech-in-noise listening among older adults with age-related hearing loss.Frontiers in aging neuroscience · 2026Article
- Disrupted structural covariance network in presbycusis patients: evidence from a large sample mri-based morphometric study.Frontiers in aging neuroscience · 2026Article
- Hearing Loss, Brain Structure, Cognition, and Dementia Risk in the Framingham Heart Study.JAMA network open · 2025Article
- A genome-wide association study about presbycusis and brain cortical structure: Neuroimaging traits from a Mendelian randomization study.Journal of otology · 2025Article
- Functional Near-Infrared Spectroscopy Analysis of the Cognitive Functions of Elderly Patients With Hearing Loss.Journal of audiology & otology · 2025Article
- COCHLEA: Longitudinal Cognitive Performance of Older Adults with Hearing Loss and Cochlear Implants at 4.5-Year Follow-Up.Brain sciences · 2024Article
- Aging-associated sensory decline and Alzheimer's disease.Molecular neurodegeneration · 2024Review
- Ayurvedic Management of Presbycusis (Project TOPMAC): Protocol for an Exploratory Randomized Controlled Trial.JMIR research protocols · 2024Article
- Neurovascular coupling dysfunction associated with cognitive impairment in presbycusis.Brain communications · 2024Article
- Evaluation of the Cognitive Function of Adults with Severe Hearing Loss Pre- and Post-Cochlear Implantation Using Verbal Fluency Testing.Journal of clinical medicine · 2023Article
- Neurochemical and functional reorganization of the cognitive-ear link underlies cognitive impairment in presbycusis.NeuroImage · 2023Article
- Mapping cerebral atrophic trajectory from amnestic mild cognitive impairment to Alzheimer's disease.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Presbycusis (PC) is characterized by bilateral sensorineural hearing loss at high frequencies and speech-perception difficulties in noisy environments and has a strikingly detrimental impact on cognitive function. As the neural consequences of PC may involve the whole brain, we hypothesized that patients with PC would show structural alterations not only in the auditory cortex but also in the cortexes involved in cognitive function. The purpose of this study was to use surface-based morphometry (SBM) analysis to elucidate whole-brain structural differences between patients with PC and age-matched normal hearing controls. Three-dimensional T1-weighted MR images of 26 patients with mild PC and 26 age-, sex- and education-matched healthy controls (HCs) were acquired. All participants underwent a battery of neuropsychological tests. Our results revealed gray matter atrophy in several auditory cortical areas, nodes of the default mode network (DMN), including the bilateral precuneus and inferior parietal lobule, the right posterior cingulate cortex (PCC), and the right insula of patients with PC compared to that in the HCs. Our findings also revealed that hearing loss was associated with reduced gray matter volume in the right primary auditory cortex of patients with PC. Moreover, structural alterations in the nodes of the DMN were associated with cognitive impairments in PC patients. Additionally, this study provides evidence that a thicker right insula is associated with better speech perception in patients with PC. Based on these findings, we argue that the onset of PC seems to trigger its own cascade of conditions, including a need for increased cognitive resources during speech comprehension, which might lead to auditory and cognition-related cortical reorganization.
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