ArticleIndian journal of psychiatry
Efficacy of buprenorphine and clonidine in opioid detoxification: A hospital- based study.
Article in Indian journal of psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Outpatient-based buprenorphine-assisted opioid withdrawal management: A preliminary prospective observational study.Indian journal of psychiatry · 2025Article
- A Practical Approach to Acute Postoperative Pain Management in Chronic Pain Patients.Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses · 2020Article
- Relationship between the Level of Motivation and Personality Disorder in Patients with Opioid Dependence Syndrome.Indian journal of psychological medicineArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe need for effective and accepted method for opioid detoxification is ever increasing. Sublingual buprenorphine and oral clonidine have been effective in opioid detoxification. As often, there is a great variation in the dosage of buprenorphine and clonidine prescribed by the clinicians; hence, there is a felt need to find an effective dosage for a favorable outcome of opioid detoxification.
objectiveThe objective of this study was to compare the effectiveness of different doses of sublingual buprenorphine and clonidine in opioid detoxification. MATERIALS AND
methodsA total of 100 patients with the diagnosis of opioid dependence as per the international classification of diseases-10 criteria were recruited for this study. Participants were assigned randomly into four groups - low-dose clonidine, high-dose clonidine, low-dose sublingual buprenorphine, and high sublingual dose buprenorphine using a computer-generated random number table, resulting in 25, 26, 23, and 26 patients in each group, respectively.
resultsThe four groups had comparable scores on all the items of "stages of change readiness and treatment eagerness scale" for the assessment of motivation at baseline. Progressive decrease in withdrawal score was seen in all the groups on "clinical opiate withdrawal scale" and "subjective opiate withdrawal scale."
conclusionFrom the current study, we can infer that both low and high doses of buprenorphine and clonidine are comparable regarding controlling withdrawal.
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