ArticleNature2018
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 187 papers.
0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed
13.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
187 citing papers in PubMed, 277 citations in OpenAlex.
- Article
- Scalable context-dependent single-cell eQTL mapping reveals disease-relevant regulatory variation beyond static models.medRxiv : the preprint server for health sciences · 2026Article
- Ferroptosis in T cells: mechanisms, biology and translational opportunities.Nature reviews. Immunology · 2026Review
- Endogenous metabolite signaling orchestrates tumor immune evasion.Cell insight · 2026Review
- The Metabolic Architecture of Glaucoma: A Unified Framework of Cofactor Failure and Kynurenine Dysregulation.International journal of molecular sciences · 2026Review
- Purine salvage pathway protects CD8Nature immunology · 2026Article
- Diet-induced metabolic memory shapes CD8Nature immunology · 2026Article
- Machine learning integration of multi-omics data develops a sarcomatoid-related renal cell carcinoma score (SARS) for prognosis stratification and guiding therapy.Translational andrology and urology · 2026Article
- Mitochondria in T‑cell tumor immunity and tumor therapies targeting mitochondria (Review).Oncology reports · 2026Review
- IMP metabolic mechanisms and IMPDH targeting strategies in tumor metabolic reprogramming and therapy (Review).International journal of molecular medicine · 2026Review
- Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity.Science advances · 2026Article
- Spatial single-cell multiomics reveals peripheral immune dysfunction in Parkinson's and inflammatory bowel disease.NPJ Parkinson's disease · 2026Article
- Transcriptional regulation of the GTP cyclohydrolase I gene via the NF-κB pathway by bacterial and viral immune stimulants.Journal of biochemistry · 2026Article
- Post-translational modifications in ferroptosis: mechanisms and therapeutic potential.International journal of biological sciences · 2026Review
- The interplay mechanisms between gut microbiota and ferroptosis in inflammatory bowel disease.Frontiers in immunology · 2026Review
- Iron as an immunometabolic signal in infection and inflammation.Frontiers in immunology · 2026Review
- Multi-omics integration reveals inhibitory effects of carbon ion radiation on lung adenocarcinoma proliferation.Frontiers in public health · 2026Article
- Iron and the immune system.Nature reviews. Immunology · 2025Review
- Review
- Mechanistic roles and intervention strategies involving gut microbiota, amino acid metabolism, and the tumor immune microenvironment in MAFLD-HCC progression.Clinical and experimental medicine · 2025Review
127 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
41 authors at 20 institutions in 8 countries.
Shane J F CroninIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Corey SeehusDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Adelheid WeidingerLudwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Vienna, Austria.
Sebastien TalbotDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Sonja ReissigInstitute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Markus SeifertDepartment of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria.
Yann PiersonInstitute of Chemical Sciences and Engineering, Institute of Bioengineering, National Centre of Competence in Research (NCCR) in Chemical Biology, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Eileen McNeillDivision of Cardiovascular Medicine, British Heart Foundation Centre for Research Excellence, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Maria Serena LonghiDivision of Gastroenterology and Liver Center, Department of Medicine, Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School (HMS), Harvard University, Boston, MA, USA.
Bruna Lenfers TurnesLABOX, Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
Taras KreslavskyResearch Institute of Molecular Pathology, Vienna Biocenter, Campus-Vienna-Biocenter 1, Vienna, Austria.
Melanie KoglerIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
David HoffmannIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Melita TicevicIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Débora da Luz SchefferLABOX, Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
Luigi TortolaIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Domagoj CikesIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Alexander JaisDepartment of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.
Manu RangachariDepartment of Neurosciences, Centre de Recherche de CHU de Québec-Université Laval, Québec, Québec, Canada.
Shuan RaoIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Magdalena PaolinoKarolinska Institute, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.
Maria NovatchkovaResearch Institute of Molecular Pathology, Vienna Biocenter, Campus-Vienna-Biocenter 1, Vienna, Austria.
Martin AichingerResearch Institute of Molecular Pathology, Vienna Biocenter, Campus-Vienna-Biocenter 1, Vienna, Austria.
Lee BarrettDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Alban LatremoliereNeurosurgery Department, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Gerald WirnsbergerApeiron Biologics AG, Vienna, Austria.
Guenther LametschwandtnerApeiron Biologics AG, Vienna, Austria.
Meinrad BusslingerResearch Institute of Molecular Pathology, Vienna Biocenter, Campus-Vienna-Biocenter 1, Vienna, Austria.
Stephen ZichaQuartet Medicine, 400 Technology Square, Cambridge, MA, USA.
Alexandra LatiniDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Simon C RobsonDivision of Cardiovascular Medicine, British Heart Foundation Centre for Research Excellence, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Ari WaismanInstitute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Nick AndrewsDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Michael CostiganDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Keith M ChannonDivision of Cardiovascular Medicine, British Heart Foundation Centre for Research Excellence, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Guenter WeissDepartment of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria.
Andrey V KozlovLudwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Vienna, Austria.
Mark TebbeDepartment of Molecular Medicine, Faculty of Medicine, Université Laval, Québec, Quebec, Canada.
Kai JohnssonInstitute of Chemical Sciences and Engineering, Institute of Bioengineering, National Centre of Competence in Research (NCCR) in Chemical Biology, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Clifford J WoolfDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA. clifford.woolf@childrens.harvard.edu.
Josef M PenningerIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria. josef.penninger@imba.oeaw.ac.at.
Austrian Academy of Sciences · ATBoston Children's Hospital · USJohn Radcliffe Hospital · GBApeiron Biologics (Austria) · ATÉcole Polytechnique Fédérale de Lausanne · CHLudwig Boltzmann Institute for Experimental and Clinical Traumatology · ATResearch Institute of Molecular Pathology · ATUniversidade Federal de Santa Catarina · BRUniversité Laval · CAUniversity Medical Center of the Johannes Gutenberg University Mainz · DEBeth Israel Deaconess Medical Center · USHarvard University · USInnsbruck Medical University · ATInstitute of Molecular Biotechnology · ATJohns Hopkins University · USKarolinska Institutet · SEKarolinska University Hospital · SEMax Planck Institute for Metabolism Research · DEUniversität Innsbruck · ATUniversité de Montréal · CA
Funding
Unravelling Mechanisms and Novel Therapeutic Targets for Peripheral Neuropathy and Neuropathic Pain (Diversity Supplement)R35NS105076 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WOOLF, CLIFFORD J · 2018 to 2025
$9.5MNeural Plasticity and Inflammatory PainR37NS039518 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WOOLF, CLIFFORD J · 2011 to 2017
$4.7MImmunomodulatory effects of bilirubin are mediated through aryl hydrocarbon receptor, O2 and purinergic pathwaysR01DK108894 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LONGHI, MARIA SERENA · 2017 to 2021
$2.0MDirected Purinergic Signaling as Immunotherapy in LeukemiaR21CA221702 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI AVIGAN, DAVID E., ROBSON, SIMON C. · 2018 to 2019
$413kBritish Heart Foundation RG/07/003/23133British Heart Foundation RG/12/5/29576British Heart Foundation RG/17/10/32859NCI NIH HHS R21 CA221702NIDDK NIH HHS R01 DK108894NINDS NIH HHS R35 NS105076NINDS NIH HHS R37 NS039518
Abstract
Genetic regulators and environmental stimuli modulate T cell activation in autoimmunity and cancer. The enzyme co-factor tetrahydrobiopterin (BH4) is involved in the production of monoamine neurotransmitters, the generation of nitric oxide, and pain
Indexed as
Administration, OralAlcohol OxidoreductasesAnimalsAutoimmune DiseasesBiopterinsCell Line, TumorCell ProliferationCoenzymesEnzyme InhibitorsFemaleGTP CyclohydrolaseHumansHypersensitivityIronKynurenineMaleAlcohol OxidoreductasesBiopterinsCoenzymesEnzyme InhibitorsGTP CyclohydrolaseIronKynureninesapropterinsepiapterin reductase
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.