Evidence map›Paper›PMID 30405236›Full record

ArticleNature2018

Abiotic synthesis of amino acids in the recesses of the oceanic lithosphere.

Bénédicte Ménez, Céline Pisapia, Muriel Andreani, Frédéric Jamme, Quentin P Vanbellingen, Alain Brunelle, Laurent Richard, Paul Dumas, Matthieu Réfrégiers

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
16.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 244 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Abiotic CONature communications · 2026
    Article
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  6. Article
  7. Article
  8. Article
  9. Article
  10. Prebiotic organic compounds in samples of asteroid Bennu indicate heterogeneous aqueous alteration.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Organic geochemical evidence for life in Archean rocks identified by pyrolysis-GC-MS and supervised machine learning.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Order of amino acid recruitment into the genetic code resolved by last universal common ancestor's protein domains.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Article
  19. Unraveling abiotic organic synthesis pathways in the mafic crust of mid-ocean ridges.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Bénédicte MénezInstitut de Physique du Globe de Paris, Sorbonne Paris Cité, Université Paris Diderot, CNRS, Paris, France. muriel.andreani@univ-lyon1.fr.
Céline PisapiaInstitut de Physique du Globe de Paris, Sorbonne Paris Cité, Université Paris Diderot, CNRS, Paris, France.
Muriel AndreaniLaboratoire de Géologie de Lyon: Terre, Planètes, Environnement, UMR5276, ENS-Université Lyon I, Villeurbanne, France.
Frédéric JammeSynchrotron SOLEIL, Gif-sur-Yvette, France.
Quentin P VanbellingenInstitut de Chimie des Substances Naturelles, CNRS UPR2301, Université Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France.
Alain BrunelleInstitut de Chimie des Substances Naturelles, CNRS UPR2301, Université Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France.
Laurent RichardNazarbayev University, School of Mining & Geosciences, Astana, Kazakhstan.
Paul DumasSynchrotron SOLEIL, Gif-sur-Yvette, France.
Matthieu RéfrégiersSynchrotron SOLEIL, Gif-sur-Yvette, France.
Synchrotron soleil · FRInstitut de Chimie des Substances Naturelles · FRLaboratoire de Géologie de Lyon : Terre, Planètes et Environnement · FRNazarbayev University · KZUniversité Paris Cité · FRUniversité Paris-Saclay · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abiotic hydrocarbons and carboxylic acids are known to be formed on Earth, notably during the hydrothermal alteration of mantle rocks. Although the abiotic formation of amino acids has been predicted both from experimental studies and thermodynamic calculations, its occurrence has not been demonstrated in terrestrial settings. Here, using a multimodal approach that combines high-resolution imaging techniques, we obtain evidence for the occurrence of aromatic amino acids formed abiotically and subsequently preserved at depth beneath the Atlantis Massif (Mid-Atlantic Ridge). These aromatic amino acids may have been formed through Friedel-Crafts reactions catalysed by an iron-rich saponite clay during a late alteration stage of the massif serpentinites. Demonstrating the potential of fluid-rock interactions in the oceanic lithosphere to generate amino acids abiotically gives credence to the hydrothermal theory for the origin of life, and may shed light on ancient metabolisms and the functioning of the present-day deep biosphere.

Indexed as

Models, ChemicalOrigin of LifeAluminum SilicatesAtlantic OceanClayEvolution, ChemicalFluorescenceIronTryptophanAluminum SilicatesClayIronsaponiteTryptophan

Identifiers

PMID30405236
OpenAlexW2900431189

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.