ArticleScientific reports2018
Proton minibeam radiation therapy widens the therapeutic index for high-grade gliomas.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 104 citations in OpenAlex.
- Impact of millimeter-scale target motion on the precision of spatially fractionated radiation therapy using proton minibeams.Medical physics · 2026Article
- Roadmap for the implementation of particle minibeam therapy.Medical physics · 2026Review
- Impact of collimator misalignments on dosimetric robustness in proton minibeam radiotherapy using an automated measurement setup.Medical physics · 2026Article
- Megavoltage photon minibeam production through the embedded multi-leaf collimator of a clinical linac: A dosimetric characterization.Medical physics · 2026Article
- Monte Carlo-based characterization of proton minibeam radiation therapy across clinically relevant beam parameters.Physics and imaging in radiation oncology · 2026Article
- Spatially fractionated radiation therapy (SFRT): a scoping review of dosimetric and biological evidence supporting a valley dose-driven translational framework.Radiation oncology (London, England) · 2026Article
- Minibeam radiation therapy does not induce canonical immunogenic cell death or cGAS-STING activation in glioblastoma and astrocyte monocultures.Scientific reports · 2026Article
- FLASH radiotherapy as an emerging paradigm in radioimmunotherapy: biological rationale, preclinical evidence, and translational roadmap.Frontiers in immunology · 2026Review
- Technical evaluation of non-coplanar lattice radiotherapy: achieving directional VPDR uniformity with a 5-mm leaf width multi-leaf collimator.Frontiers in oncology · 2026Article
- Evaluation of Proton Minibeam Radiotherapy on Antitumor Immune Responses in a Rat Model of Glioblastoma.Cancer immunology research · 2025Article
- Collimated and non-collimated proton minibeam irradiation using SIRMIO: a simulation study.Acta oncologica (Stockholm, Sweden) · 2025Article
- Development of a preclinical X-rays minibeam Monte Carlo treatment planning system.Scientific reports · 2025Article
- From pre-clinical studies to human treatment with proton-minibeam radiation therapy: adapted Idea, Development, Exploration, Assessment and Long-term evaluation (IDEAL) framework for innovation in radiotherapy.Clinical and translational radiation oncology · 2025Review
- Photon mini-GRID therapy for preoperative breast cancer tumor treatment: A treatment plan study.Medical physics · 2025Article
- The temporal response of a glioma cell population to irradiation: modelling the effect of dose and cell density.Royal Society open science · 2025Article
- Carbon minibeam radiation therapy results in tumor growth delay in an osteosarcoma murine model.Scientific reports · 2025Article
- Monte Carlo modeling of a commercial machine and experimental setup for FLASH-minibeam irradiations with electrons.Medical physics · 2025Article
- Proton minibeam radiotherapy: a review.Frontiers in oncology · 2025Review
- Are we overestimating proton minibeam therapy effectiveness through physical dose metrics?Frontiers in oncology · 2025Article
- Particle Beam Radiobiology Status and Challenges: A PTCOG Radiobiology Subcommittee Report.International journal of particle therapy · 2024Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proton minibeam radiation therapy (pMBRT) is a novel strategy which has already shown a remarkable reduction in neurotoxicity as to compared with standard proton therapy. Here we report on the first evaluation of tumor control effectiveness in glioma bearing rats with highly spatially modulated proton beams. Whole brains (excluding the olfactory bulb) of Fischer 344 rats were irradiated. Four groups of animals were considered: a control group (RG2 tumor bearing rats), a second group of RG2 tumor-bearing rats and a third group of normal rats that received pMBRT (70 Gy peak dose in one fraction) with very heterogeneous dose distributions, and a control group of normal rats. The tumor-bearing and normal animals were followed-up for 6 months and one year, respectively. pMBRT leads to a significant tumor control and tumor eradication in 22% of the cases. No substantial brain damage which confirms the widening of the therapeutic window for high-grade gliomas offered by pMBRT. Additionally, the fact that large areas of the brain can be irradiated with pMBRT without significant side effects, would allow facing the infiltrative nature of gliomas.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.