ArticleScientific reports2018
Brain structural connectivity and neuroticism in healthy adults.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 30 citations in OpenAlex.
- Trait-Relevant Tasks Improve Personality Prediction From Structural-Functional Brain Network Coupling.Human brain mapping · 2026Article
- EEG Sensor-Based Computational Model for Personality and Neurocognitive Health Analysis Under Social Stress.Sensors (Basel, Switzerland) · 2025Article
- Trait-Relevant Tasks Improve Personality Prediction from Structural-Functional Brain Network Coupling.bioRxiv : the preprint server for biology · 2025Article
- Network-based mapping and neurotransmitter architecture of gray matter correlates of neuroticism.Frontiers in systems neuroscience · 2025Article
- Neuroticism polygenic risk predicts conversion from mild cognitive impairment to Alzheimer's disease by impairing inferior parietal surface area.Human brain mapping · 2024Article
- Combined effects of neuroticism and negative emotional context on spontaneous EEG dynamics.Social cognitive and affective neuroscience · 2024Article
- Emotional Vulnerability in Adolescents (EVA) Longitudinal Study: Identifying individual differences in symptoms of adolescent depression and anxiety and their biopsychosocial mechanisms based on demographic and mental health characteristics.Wellcome open research · 2024Article
- Statistical perspective on functional and causal neural connectomics: The Time-Aware PC algorithm.PLoS computational biology · 2022Article
- Integration of structural brain networks is related to openness to experience: A diffusion MRI study with CSD-based tractography.Frontiers in neuroscience · 2022Article
- "Nothing to see here": No structural brain differences as a function of thePersonality neuroscience · 2022Review
- Enhanced sensitivity to optimistic cues is manifested in brain structure: a voxel-based morphometry study.Social cognitive and affective neuroscience · 2021Article
- Article
- Self-efficacy as a mediator of neuroticism and perceived stress: Neural perspectives on healthy aging.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the neural correlates of the neurotic brain is important because neuroticism is a risk factor for the development of psychopathology. We examined the correlation between brain structural networks and neuroticism based on NEO Five-Factor Inventory (NEO-FFI) scores. Fifty-one healthy participants (female, n = 18; male, n = 33; mean age, 38.5 ± 11.7 years) underwent the NEO-FFI test and magnetic resonance imaging (MRI), including diffusion tensor imaging and 3D T1WI. Using MRI data, for each participant, we constructed whole-brain interregional connectivity matrices by deterministic tractography and calculated the graph theoretical network measures, including the characteristic path length, global clustering coefficient, small-worldness, and betweenness centrality (BET) in 83 brain regions from the Desikan-Killiany atlas with subcortical segmentation using FreeSurfer. In relation to the BET, neuroticism score had a negative correlation in the left isthmus cingulate cortex, left superior parietal, left superior temporal, right caudal middle frontal, and right entorhinal cortices, and a positive correlation in the bilateral frontal pole, left caudal anterior cingulate cortex, and left fusiform gyrus. No other measurements showed significant correlations. Our results imply that the brain regions related to neuroticism exist in various regions, and that the neuroticism trait is likely formed as a result of interactions among these regions. This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas (Comprehensive Brain Science Network) from the Ministry of Education, Science, Sports and Culture of Japan.
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