Evidence map›Paper›PMID 30405145›Full record

ArticleScientific reports2018

Segmentation of the Proximal Femur from MR Images using Deep Convolutional Neural Networks.

Cem M Deniz, Siyuan Xiang, R Spencer Hallyburton, Arakua Welbeck, James S Babb, Stephen Honig, Kyunghyun Cho, Gregory Chang

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 136 citations in OpenAlex.

  1. Article
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  3. Osteoporosis: current diagnostic possibilities, a literature review.Przeglad menopauzalny = Menopause review · 2026
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  11. Machine learning is changing osteoporosis detection: an integrative review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Review
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Cem M DenizDepartment of Radiology, New York University School of Medicine, New York, NY, 10016, USA. cem.deniz@nyulangone.org.ORCID http://orcid.org/0000-0001-8809-5945
Siyuan XiangCenter for Data Science, New York University, New York, NY, 10012, USA.
R Spencer HallyburtonHarvard College, Cambridge, MA, 02138, USA.
Arakua WelbeckBernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, New York, NY, 10016, USA.
James S BabbBernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, New York, NY, 10016, USA.
Stephen HonigOsteoporosis Center, Hospital for Joint Diseases, New York University Langone Medical Center, New York, NY, 10003, USA.
Kyunghyun ChoCenter for Data Science, New York University, New York, NY, 10012, USA.
Gregory ChangDepartment of Radiology, New York University School of Medicine, New York, NY, 10016, USA.
New York University · USCourant Institute of Mathematical Sciences · USHarvard College Observatory · USNYU Langone Health · US

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dmitry S Novikov · 2014 to 2026
$19.3M
MRI of Proximal Femur Microarchitecture as a Biomarker of Bone QualityR01AR066008 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHANG, GREGORY · 2014 to 2018
$2.8M
MRI of Proximal Femur Bone Quality for Monitoring Short-Term Response to Osteoporosis TherapyR01AR073851 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHANG, GREGORY · 2019 to 2023
$2.8M
Translation of Hip Microarchitectural Assessment Technology to the Clinic to Diagnose Glucocorticoid-Induced OsteoporosisR01AR070131 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHANG, GREGORY · 2016 to 2020
$2.7M
NIAMS NIH HHS R01 AR066008NIAMS NIH HHS R01 AR070131NIAMS NIH HHS R01 AR073851NIBIB NIH HHS P41 EB017183
6 · The paper itself

Abstract

Magnetic resonance imaging (MRI) has been proposed as a complimentary method to measure bone quality and assess fracture risk. However, manual segmentation of MR images of bone is time-consuming, limiting the use of MRI measurements in the clinical practice. The purpose of this paper is to present an automatic proximal femur segmentation method that is based on deep convolutional neural networks (CNNs). This study had institutional review board approval and written informed consent was obtained from all subjects. A dataset of volumetric structural MR images of the proximal femur from 86 subjects were manually-segmented by an expert. We performed experiments by training two different CNN architectures with multiple number of initial feature maps, layers and dilation rates, and tested their segmentation performance against the gold standard of manual segmentations using four-fold cross-validation. Automatic segmentation of the proximal femur using CNNs achieved a high dice similarity score of 0.95 ± 0.02 with precision = 0.95 ± 0.02, and recall = 0.95 ± 0.03. The high segmentation accuracy provided by CNNs has the potential to help bring the use of structural MRI measurements of bone quality into clinical practice for management of osteoporosis.

Indexed as

Image Processing, Computer-AssistedMagnetic Resonance ImagingNeural Networks, ComputerAlgorithmsFemurHumansMachine LearningMammographyReproducibility of ResultsROC Curve

Identifiers

PMID30405145
PMCPMC6220200
OpenAlexW2609546627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.