Evidence map›Paper›PMID 30405140›Full record

ArticleScientific reports2018

Brain volumetric alterations accompanied with loss of striatal medium-sized spiny neurons and cortical parvalbumin expressing interneurons in Brd1

Per Qvist, Simon F Eskildsen, Brian Hansen, Mohammad Baragji, Steffen Ringgaard, Jolien Roovers, Veerle Paternoster, Simon Molgaard, Thomas Juhl Corydon, Hans Stødkilde-Jørgensen and 6 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  3. A curious concept of CNS clearance.Nature neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Per QvistiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark. per.q@biomed.au.dk.
Simon F EskildsenCenter of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-4242-9158
Brian HansenCenter of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Mohammad BaragjiDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Steffen RinggaardThe MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-5353-7379
Jolien RooversDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-8599-1792
Veerle PaternosteriPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-6769-7397
Simon MolgaardDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Thomas Juhl CorydonDepartment of Biomedicine, Aarhus University, Aarhus, Denmark. corydon@biomed.au.dk.ORCID http://orcid.org/0000-0003-3588-6350
Hans Stødkilde-JørgensenThe MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Simon GlerupDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Ole MorsiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Gregers WegenerTranslational Neuropsychiatry Unit, Aarhus University Hospital, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-0081-0068
Jens R NyengaardCore Center for Molecular Morphology, Section for Stereology and Microscopy, Centre for Stochastic Geometry and Advanced Bioimaging, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Anders D BørglumiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Jane H ChristenseniPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-0009-2991
Aarhus University · DKAarhus University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schizophrenia is a common and severe mental disorder arising from complex gene-environment interactions affecting brain development and functioning. While a consensus on the neuroanatomical correlates of schizophrenia is emerging, much of its fundamental pathobiology remains unknown. In this study, we explore brain morphometry in mice with genetic susceptibility and phenotypic relevance to schizophrenia (Brd1

Indexed as

AnimalsBiomarkersBrainBromodomain Containing ProteinsCell CountCorpus StriatumGene ExpressionGene Expression ProfilingHeterozygoteHistone AcetyltransferasesHumansImmunohistochemistryInterneuronsMiceMice, KnockoutNeuronsBiomarkersBRD1 protein, mouseBromodomain Containing ProteinsHistone AcetyltransferasesParvalbumins

Identifiers

PMID30405140
PMCPMC6220279
OpenAlexW2899288958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.