ArticleNature communications2018
A retrieval-specific mechanism of adaptive forgetting in the mammalian brain.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The infralimbic, but not the prelimbic cortex is needed for a complex olfactory memory task.Neurobiology of learning and memory · 2025Article
- The Infralimbic, but not the Prelimbic Cortex is needed for a Complex Olfactory Memory Task.bioRxiv : the preprint server for biology · 2024Article
- Memory persistence: from fundamental mechanisms to translational opportunities.Translational psychiatry · 2024Review
- The Development of Flexible Problem Solving: An Integrative Approach.Journal of Intelligence · 2023Review
- Dopamine Modulates Adaptive Forgetting in Medial Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Hippocampal-medial prefrontal cortex network dynamics predict performance during retrieval in a context-guided object memory task.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Forgetting as a form of adaptive engram cell plasticity.Nature reviews. Neuroscience · 2022Review
- Prefrontal-hippocampal interactions supporting the extinction of emotional memories: the retrieval stopping model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Post-training stimulation of the right dorsolateral prefrontal cortex impairs working memory training performance.Journal of neuroscience research · 2021Article
- Understanding the dynamic and destiny of memories.Neuroscience and biobehavioral reviews · 2021Review
- What do laboratory-forgetting paradigms tell us about use-inspired forgetting?Cognitive research: principles and implications · 2021Article
- AMPA Receptors: A Key Piece in the Puzzle of Memory Retrieval.Frontiers in human neuroscience · 2021Review
- Goffin's Cockatoos (Frontiers in psychology · 2021Article
- Does retrieving a memory insulate it against memory inhibition? A retroactive interference study.Memory (Hove, England) · 2020Article
- The medial prefrontal cortex is needed for resolving interference even when there are no changes in task rules and strategies.Behavioral neuroscience · 2020Article
- Unintentional forgetting is beyond cognitive control.Cognitive research: principles and implications · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Forgetting is a ubiquitous phenomenon that is actively promoted in many species. How and whether organisms' behavioral goals drive which memories are actively forgotten is unknown. Here we show that processes essential to controlling goal-directed behavior trigger active forgetting of distracting memories that interfere with behavioral goals. When rats need to retrieve particular memories to guide exploration, it reduces later retention of other memories encoded in that environment. As with humans, this retrieval-induced forgetting is competition-dependent, cue-independent and reliant on prefrontal control: Silencing the medial prefrontal cortex with muscimol abolishes the effect. cFos imaging reveals that prefrontal control demands decline over repeated retrievals as competing memories are forgotten successfully, revealing a key adaptive benefit of forgetting. Occurring in 88% of the rats studied, this finding establishes a robust model of how adaptive forgetting harmonizes memory with behavioral demands, permitting isolation of its circuit, cellular and molecular mechanisms.
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Registered trials
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