ArticleTranslational psychiatry2018
Maternal depression during pregnancy and cord blood DNA methylation: findings from the Avon Longitudinal Study of Parents and Children.
Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Epigenome-wide association studies of prenatal maternal mental health and infant epigenetic profiles: a systematic review.Translational psychiatry · 2023Pooled it
- Maternal Mental Health and Offspring Brain Development: An Umbrella Review of Prenatal Interventions.Biological psychiatry · 2023Pooled it
- Stress During Pregnancy and Epigenetic Modifications to Offspring DNA: A Systematic Review of Associations and Implications for Preterm Birth.The Journal of perinatal & neonatal nursingPooled it
- Maternal antenatal depression and offspring DNA methylation.Journal of affective disorders · 2026Article
- The fetal exposome: cellular and epigenetic programming of neonatal immune function.Frontiers in immunology · 2026Review
- Relationship between global warming and autism spectrum disorder from 1990 to 2019.BJPsych open · 2024Article
- Association between maternal perinatal stress and depression and infant DNA methylation in the first year of life.Translational psychiatry · 2024Article
- The Mood and Resilience in Offspring (MARIO) project: a longitudinal cohort study among offspring of parents with and without a mood disorder.BMC psychiatry · 2024Observational
- Association between Maternal Perinatal Stress and Depression on Infant DNA Methylation in the First Year of Life.Research square · 2024Article
- Prenatal maternal stress is associated with site-specific and age acceleration changes in maternal and newborn DNA methylation.Epigenetics · 2023Article
- Postpartum depression: aetiology, pathogenesis and the role of nutrients and dietary supplements in prevention and management.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Review
- Analysis of Posttraumatic Stress Disorder Gene Expression Profiles in a Prospective, Community-Based Cohort.Human biology · 2023Article
- Maternal depression and adverse neighbourhood conditions during pregnancy are associated with gestational epigenetic age deceleration.Epigenetics · 2022Article
- Perinatal exposure to fluoxetine and maternal adversity affect myelin-related gene expression and epigenetic regulation in the corticolimbic circuit of juvenile rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Maternal prenatal depressive symptoms and toddler behavior: an umbilical cord blood epigenome-wide association study.Translational psychiatry · 2022Article
- Newborn DNA methylation and asthma acquisition across adolescence and early adulthood.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Article
- Association Between Maternal Adverse Childhood Experiences and Neonatal SCG5 DNA Methylation-Effect Modification by Prenatal Home Visiting.American journal of epidemiology · 2022Article
- Periconception and Prenatal Exposure to Maternal Perceived Stress and Cord Blood DNA Methylation.Epigenetics insights · 2022Article
- Leukocyte methylomic imprints of exposure to the genocide against the Tutsi in Rwanda: a pilot epigenome-wide analysis.Epigenomics · 2022Article
- Association between maternal depression during pregnancy and newborn DNA methylation.Translational psychiatry · 2021Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Up to 13% of women may experience symptoms of depression during pregnancy or in the postpartum period. Depression during pregnancy has been associated with an increased risk of adverse neurodevelopmental outcomes in the child and epigenetic mechanisms could be one of the biological pathways to explain this association. In 844 mother-child pairs from the Avon Longitudinal Study of Parents and Children, we carried out an epigenome-wide association study (EWAS) to investigate associations between prospectively collected data on maternal depression ascertained by the Edinburgh Postnatal Depression Scale in pregnancy and DNA methylation in the cord blood of newborn offspring. In individual site analysis, we identified two CpG sites associated with maternal depression in the middle part of pregnancy. In our regional analysis, we identified 39 differentially methylated regions (DMRs). Seven DMRs were associated with depression at any time point during pregnancy, 7 associated with depression in mid-pregnancy, 23 were associated with depression in late pregnancy, and 2 DMRs were associated with depression throughout pregnancy. Several of these map to genes associated with psychiatric disease and brain development. We attempted replication in The Generation R Study and could not replicate our results. Although our findings in ALSPAC suggest that maternal depression could be associated with cord blood DNA methylation the results should be viewed as preliminary and hypothesis generating until further replicated in a larger sample.
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