ReviewThe American journal of case reports2018
A Rare Case of Primary Hyperparathyroidism Caused by a Giant Solitary Parathyroid Adenoma.
Review in The American journal of case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Giant parathyroid tumours in primary hyperparathyroidism: a systematic review.Langenbeck's archives of surgery · 2022Pooled it
- Comparison of the two treatment methods in primary hyperparathyroidism due to solitary parathyroid adenoma, Ultrasound-guided percutaneous alcohol ablation vs. parathyroidectomy: a randomized controlled trial.BMC endocrine disorders · 2025Trial
- An exceptionally rare case of a giant parathyroid adenoma with carcinoma-like presentation.Hormones (Athens, Greece) · 2025Article
- A Rare Occurrence of Ectopic Parathyroid Carcinoma Presenting as a Case of Recurrent Fractures.Cureus · 2023Article
- Surgical challenges of giant parathyroid adenomas weighing 10 g or more.Journal of endocrinological investigation · 2023Article
- Endocrinological cause behind recurrent miscarriages: primary hyperparathyroidism.Endocrinology, diabetes & metabolism case reports · 2023Article
- Overview of the 2022 WHO Classification of Parathyroid Tumors.Endocrine pathology · 2022Review
- Gastric Outlet Obstruction Following Recurrent Pancreatitis Uncovers a Giant Parathyroid Adenoma: A Case Report.Journal of the ASEAN Federation of Endocrine Societies · 2022Article
- Giant Parathyroid Adenoma-Associated Fracture, Not All Lytic Bone Lesions areCase reports in medicine · 2022Article
- Primary hyperparathyroidism-related giant parathyroid adenoma (Review).Experimental and therapeutic medicine · 2022Review
- Mediastinal ectopic parathyroid adenomas: diagnostic and therapeutic challenge.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2021Article
- [Sporadic primary hyperparathyroidism with multiple parathyroid adenomas].Problemy endokrinologii · 2021Article
- Giant parathyroid adenoma: a case report and review of the literature.Journal of medical case reports · 2019Review
- Hypercalcemic Crisis Caused by a Parathyroid Mass Requiring Thoracoscopic Resection.AACE clinical case reportsArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Solitary parathyroid adenomas are the leading cause of primary hyperparathyroidism in 0% to 85% of cases. Diagnosis of parathyroid adenoma is based on typical clinical presentation of hypercalcemia, biochemical profile, and modern imaging studies. The purpose of this article is to present the diagnostic and therapeutic approach used for a 73-year-old female patient with a giant parathyroid adenoma measuring 5×2.5×2.5 cm and weighing 30 grams. CASE REPORT A 73-year-old female was referred to the outpatient clinic of our Surgical Department with the diagnosis of primary hyperparathyroidism. The patient suffered from typical symptoms of hypercalcemia such as weakness, bone disease, and recurrent nephrolithiasis; she had a painless cervical mass for 5 months. Primary hyperparathyroidism was confirmed based on the patient's biochemical profile, which showed increased levels of serum calcium and parathyroid hormone. SestaMIBI scintigraphy with 99mTechnetium and cervical ultrasonography revealed a large nodule at the inferior pole of the right lobe of the thyroid gland. Intraoperatively, a giant parathyroid adenoma was found and excised. Additionally, levels of intact parathyroid hormone (IOiPTH) were determined intraoperatively and a 95% reduction was found, 20 minutes after the removal of the adenoma. CONCLUSIONS This is an extremely rare case of a giant solitary parathyroid adenoma. Diagnosis of a giant hyperfunctioning solitary parathyroid adenomas was based on clinical presentation, biochemical profile, and imaging studies. Selective treatment was based on surgical excision combined with IOiPTH levels measurement.
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