ArticleNutrients2018
Physical Exercise Improves Glycemic and Inflammatory Profile and Attenuates Progression of Periodontitis in Diabetic Rats (HFD/STZ).
Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Quercetin in the Prevention of Induced Periodontal Disease in Animal Models: A Systematic Review and Meta-Analysis.Nutrients · 2024Pooled it
- Trial
- Hyperglycemic microenvironment-driven periodontal tissue defects: pathogenic mechanisms and therapeutic advances.Frontiers in dental medicine · 2026Review
- Periodontitis and physical activity: a scoping review.Frontiers in oral health · 2026Review
- Lipocalin-2 as a fundamental protein in type 2 diabetes and periodontitis in mice.Journal of periodontology · 2025Article
- Physical exercise alone or combined with omega-3 modulates apical periodontitis induced in rats.Scientific reports · 2025Article
- Humic Acid Derived from Agricultural Biomass Mitigates Alveolar Bone Loss and Modulates Systemic Inflammatory Cytokines in Rats with Periodontitis.Current topics in medicinal chemistry · 2025Article
- The impact of physical activity on the prevalence of edentulism: an analysis of the relationships between active lifestyle and dental health.BMC public health · 2024Article
- Physical training attenuates systemic cytokine response and tissue damage triggered by apical periodontitis.Scientific reports · 2024Article
- Physical training minimizes immunological dysfunction, oxidative stress and tissue destruction on experimental periodontitis in rats.PloS one · 2024Article
- Impact of Endurance Exercise Training on Biomarkers of Aortic Endothelial Damage in Diabetic Rats.Cardiovascular therapeutics · 2024Article
- Relationship between the Social Development Index and Self-Reported Periodontal Conditions.Healthcare (Basel, Switzerland) · 2023Article
- Biochanin A Ameliorates Nephropathy in High-Fat Diet/Streptozotocin-Induced Diabetic Rats: Effects on NF-kB/NLRP3 Axis, Pyroptosis, and Fibrosis.Antioxidants (Basel, Switzerland) · 2023Article
- Aerobic exercise 3 times per week in adult rats did not influence the progression of periodontal disease.Frontiers in sports and active living · 2023Article
- Açaí (Antioxidants (Basel, Switzerland) · 2022Article
- Obesity, Bone Loss, and Periodontitis: The Interlink.Biomolecules · 2022Review
- Low Levels of Tumor Necrosis Factor-α will Prevent Periodontitis Exacerbation in Type 2 Diabetes Mellitus.European journal of dentistry · 2022Article
- Interplay Among the Oral Microbiome, Oral Cavity Conditions, the Host Immune Response, Diabetes Mellitus, and Its Associated-Risk Factors-An Overview.Frontiers in oral health · 2021Review
- The Role of Irisin in Exercise-Mediated Bone Health.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The authors aimed to evaluate the effects of physical exercise on the metabolism and progression of periodontal disease (PD), induced by ligature in diabetic rats induced by high fat diet and streptozotocin (HFD/STZ). Diabetes Mellitus (DM) was induced by four weeks of a hyperlipidic diet associated with a single low-dose of streptozotocin (35 mg/kg/animal). The exercise groups swam for 60 min/day for eight weeks (five times/week). In the last two weeks of exercise, a ligature was placed around the right and left mandibular first molars. The authors determined alveolar bone loss by morphometry. Blood biochemical profile and serum levels of IL-10 and TNF-α were evaluated by colorimetric and enzyme-linked immunosorbent assays (ELISA), respectively. The diabetic animals subjected to exercise showed decreased alveolar bone loss, lower glycemia, triacylglycerols and glycosylated hemoglobin levels than the controls. Total cholesterol and its fractions (High density lipoprotein-HDL-c, Low density lipoprotein-LDL-c and Very low density lipoprotein-VLDL-c) remained similar among the groups. Animals with PD showed higher levels of TNF-α and lower levels of IL-10, when compared to animals without PD. In diabetic animals with PD, physical exercise decreased TNF-α levels and increased IL-10 levels as well as the IL10/TNF-α ratio. In conclusion, eight weeks of physical exercise improved glycemic control and systemic inflammatory profile, and attenuated alveolar bone loss in rats with DM and PD.
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