Evidence map›Paper›PMID 30405068›Full record

ReviewGenes2018

Cystic Fibrosis Gene Therapy: Looking Back, Looking Forward.

Ashley L Cooney, Paul B McCray, Patrick L Sinn

Open access · goldAbstract readReview
In one paragraph

Review in Genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 129 citations in OpenAlex.

  1. Review
  2. Considerations for early life genetic therapies in cystic fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  3. Article
  4. Optimized AAV capsids robustly transduce airway epithelial cells.bioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Pulmonary Ionocytes Regulate Airway Surface Liquid pH in Primary Human Bronchial Epithelial Cells.American journal of respiratory and critical care medicine · 2024
    Article
  14. Highly branched poly β-amino ester/CpG-depletedMolecular therapy. Methods & clinical development · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ashley L CooneyDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. ashley-peterson@uiowa.edu.ORCID 0000-0003-2717-9138
Paul B McCrayDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. paul-mccray@uiowa.edu.
Patrick L SinnDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. patrick-sinn@uiowa.edu.ORCID 0000-0002-9746-966X
University of Iowa · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Vector CoreP01HL051670 · NHLBI · UNIVERSITY OF IOWA · PI MCCRAY, PAUL B · 1993 to 2019
$36.5M
Respiratory virus infection in early cystic fibrosis lung diseaseP01HL091842 · NHLBI · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2008 to 2022
$34.2M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Life-long phenotypic correction of CF airwaysR01HL133089 · NHLBI · UNIVERSITY OF IOWA · PI PATRICK L SINN · 2017 to 2026
$5.3M
Cystic Fibrosis Foundation SINN15XX0National Institutes of Health P01 HL-091842National Institutes of Health P01 HL-51670National Institutes of Health P30 DK-054759National Institutes of Health R01 HL-105821National Institutes of Health R01 HL-133089NHLBI NIH HHS P01 HL051670NHLBI NIH HHS P01 HL091842NHLBI NIH HHS R01 HL133089NIDDK NIH HHS P30 DK054759NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (

Indexed as

adeno-associated virusadenovirusanimal modelsclinical trialshistorylentivirusnon-viral vectorsretrovirusviral vectors

Identifiers

PMID30405068
PMCPMC6266271
OpenAlexW2900294817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.